E101
S-(−)-Eticlopride 盐酸盐
≥98% (HPLC), D2 dopamine receptor antagonist, powder
别名:
FLB 131, S-(−)-3-Chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxybenzamide 盐酸盐
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关于此项目
经验公式（希尔记法）:
C17H25ClN2O3 · HCl
化学文摘社编号:
分子量:
377.31
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
S-(−)-Eticlopride 盐酸盐, ≥98% (HPLC), powder
SMILES string
Cl.CCN1CCC[C@H]1CNC(=O)c2c(O)c(CC)cc(Cl)c2OC
InChI key
HFJFXXDHVWLIKX-YDALLXLXSA-N
InChI
1S/C17H25ClN2O3.ClH/c1-4-11-9-13(18)16(23-3)14(15(11)21)17(22)19-10-12-7-6-8-20(12)5-2;/h9,12,21H,4-8,10H2,1-3H3,(H,19,22);1H/t12-;/m0./s1
assay
≥98% (HPLC)
form
powder
optical activity
[α]27/D −7.2°, c = 0.3 in methanol(lit.)
storage condition
desiccated
color
off-white
solubility
H2O: soluble >10 mg/mL, ethanol: soluble 2.6 mg/mL, 0.1 M HCl: soluble 7 mg/mL
Quality Level
Gene Information
human ... DRD2(1813)
相关类别
Application
S-(-)-盐酸依替必利已用于星形胶质细胞-神经元共培养 和官能性磁共振成像 (fMRI) 实验。
Biochem/physiol Actions
强效和选择性 D2 多巴胺受体拮抗剂。依替必利对 DAD2 受体的特异性高于匹莫齐特或氟哌啶醇。编码D2多巴胺受体（DRD2）的基因与包括帕金森病在内的多种疾病、精神分裂症和酒精中毒易感性有关。
Preparation Note
溶液可在 4° C下储存数天
Legal Information
经 Astra AB 许可生产和销售。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Anna Niewiarowska-Sendo et al.
Acta biochimica Polonica, 65(3), 367-375 (2018-08-28)
Leukocyte adhesion to the vascular endothelium contributes to many immunological and inflammatory disorders. These processes have been shown to be mediated by bradykinin receptor type 2 (B2R) and dopamine receptor type 2 (D2R). In a previous study, we reported the
Ciliary neurotrophic factor mediates dopamine D2 receptor-induced CNS neurogenesis in adult mice
Yang P, et al.
The Journal of Neuroscience, 28(9), 2231-2241 (2008)
C Köhler et al.
European journal of pharmacology, 120(2), 217-226 (1986-01-21)
The novel substituted benzamide eticlopride, (S)-(-)-5-chloro-3-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-methoxy salicylamide hydrochloride (A38503; FLB 131), was radiolabelled to high specific activity and used for in vivo receptor binding studies in the rat brain. Intravenous injections of [3H]eticlopride resulted in a rapid accumulation of radioactivity
The dopamine D2 antagonist eticlopride accelerates extinction and delays reacquisition of food self-administration in rats
Koerber J, et al.
Behavioural Pharmacology, 24(8), 633-633 (2013)
Dopaminergic imaging of nonmotor manifestations in a rat model of Parkinson's disease by fMRI
Chen C C V, et al.
Neurobiology of Disease, 49(9), 99-106 (2013)
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