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Merck
CN

E1127

β-雌二醇17-(β-D-葡萄糖醛酸) 钠盐

≥98% (HPLC), Estradiol metabolite, powder

别名:

1,3,5(10)-Estratriene-3,17β-diol 17-glucuronide, 3,17β-Dihydroxy-1,3,5(10)-estratriene 17-glucuronide

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关于此项目

线性分子式:
C24H31O8Na
化学文摘社编号:
15087-02-2
分子量:
470.49
MDL编号:
MFCD00056557
UNSPSC代码:
51111800
PubChem化学物质编号:
24894388
NACRES:
NA.77

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产品名称

β-雌二醇17-(β-D-葡萄糖醛酸) 钠盐,

无菌性

non-sterile

方案

≥98% (HPLC)

表单

powder

溶解性

0.1 M NaOH: 10 mg/mL, clear to slightly hazy, colorless to faintly yellow

运输

ambient

储存温度

−20°C

SMILES字符串

[Na].CC12CCC3C(CCc4cc(O)ccc34)C1CCC2OC5OC(C(O)C(O)C5O)C(O)=O

InChI

1S/C24H32O8.Na.H/c1-24-9-8-14-13-5-3-12(25)10-11(13)2-4-15(14)16(24)6-7-17(24)31-23-20(28)18(26)19(27)21(32-23)22(29)30;;/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30);;

InChI key

GPLPNZUTAJWRLU-UHFFFAOYSA-N

相关类别

应用

β-Estradiol 17-(β-D-glucuronide) sodium salt has been used as a standard to determine the quantity of β-Estradiol 17-(β-D-glucuronide) during UDP-glucuronosyltransferase assay. It has also been used as a constituent of modified synthetic oviduct fluid (m-SOF) for maturation of bovine cumulus oocyte complexes (COC).

生化/生理作用

Estradiol 17-(β-D-glucuronide) (E217G) is a naturally occurring conjugated estrogen. It is formed in the liver and later excreted in bile. Increased concentrations of E217G leads to the development of cholestasis during the later stages of pregnancy, a condition which occurs with high frequency in the Dubin-Johnson syndrome.

特点和优势

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Warning

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000353229
0000353229
0000376255
0000376255
0000285933

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ATP-dependent 17-Estradiol 17-(-D-Glucuronide) Transport by Multidrug Resistance Protein (MRP) INHIBITION BY CHOLESTATIC STEROIDS
Loe DW, et al.
The Journal of Biological Chemistry, 271, 9683-9689 (1996)
Vascular endothelial growth factor has beneficial effect independent of serum components throughout oocyte maturation and early embryonic development in cattle
Luo H, et al.
Asian-Australasian Journal of Animal Sciences, 19(4), 495-499 (2006)
Vascular endothelial growth factor (VEGF) promotes the early development of bovine embryo in the presence of cumulus cells
Luo H, et al.
The Journal of Veterinary Medical Science, 64(11), 967-971 (2002)
In vitro Glucuronidation of Estradiol-17 beta by Microsomes Prepared using Liver Biopsy Specimens from Dairy Cows
Kadokawa H, et al.
The Journal of Veterinary Medical Science, 69(5), 557-559 (2007)

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