E114
EHNA 盐酸盐
≥98% (HPLC), powder, adenosine deaminase inhibitor
别名:
赤-9-氨基-& # 946;-己基-& # 945;-甲基-9H-嘌呤-9-乙醇 盐酸盐, 赤-9-（2-羟基-3-壬基）腺嘌呤 盐酸盐
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关于此项目
经验公式（希尔记法）:
C14H23N5O · HCl
化学文摘社编号:
分子量:
313.83
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
EHNA 盐酸盐, ≥98% (HPLC)
SMILES string
Cl[H].CCCCCC[C@H]([C@H](C)O)n1cnc2c(N)ncnc12
InChI
1S/C14H23N5O.ClH/c1-3-4-5-6-7-11(10(2)20)19-9-18-12-13(15)16-8-17-14(12)19;/h8-11,20H,3-7H2,1-2H3,(H2,15,16,17);1H/t10-,11+;/m0./s1
InChI key
VVDXNJRUNJMYOZ-VZXYPILPSA-N
assay
≥98% (HPLC)
storage condition
desiccated
solubility
DMSO: >10 mg/mL
H2O: >10 mg/mL
Quality Level
Gene Information
human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
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Application
EHNA盐酸盐用于处于微外植体培养基，以检查负责自噬体在轴突中运动的方向和动作。此外，它还用于核苷补充，以抑制脱氧腺苷被酶腺苷酸脱氨酶分解。
Biochem/physiol Actions
腺苷脱氨酶抑制剂。
Features and Benefits
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
General description
EHNA是一种腺苷脱氨酶抑制剂。具有抗肿瘤作用。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Adenosine deaminase inhibitor EHNA exhibits a potent anticancer effect against malignant pleural mesothelioma
Nakajima Y, et al.
Cellular Physiology and Biochemistry, 35(1), 51-60 (2015)
Sarah M Bowers et al.
Pediatric rheumatology online journal, 18(1), 54-54 (2020-07-12)
Human adenosine deaminase 2 (ADA2) is an extracellular enzyme that negatively regulates adenosine-mediated cell signaling by converting adenosine to inosine. Altered ADA2 enzyme activity has been associated with some viral infections and rheumatic diseases. The potential utility of ADA2 as
Enzyme inhibitors. 26. Bridging hydrophobic and hydrophilic regions on adenosine deaminase with some 9-(2-hydroxy-3-alkyl)adenines.
H J Schaeffer et al.
Journal of medicinal chemistry, 17(1), 6-8 (1974-01-01)
Heidi M B Lesscher et al.
Alcoholism, clinical and experimental research, 41(7), 1271-1279 (2017-04-28)
A substantial part of the risk for alcohol use disorder is determined by genetic factors. We previously used chromosome substitution (CSS) mice, to identify a quantitative trait loci (QTL) for alcohol preference on mouse chromosome 2. The aim of this
Eric Y Shin et al.
Journal of the American Heart Association, 7(2) (2018-01-15)
During myocardial ischemia/reperfusion (MI/R) injury, there is extensive release of immunogenic metabolites that activate cells of the innate immune system. These include ATP and AMP, which upregulate chemotaxis, migration, and effector function of early infiltrating inflammatory cells. These cells subsequently
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Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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