E114
EHNA 盐酸盐
≥98% (HPLC), powder, adenosine deaminase inhibitor
别名:
赤-9-氨基-& # 946;-己基-& # 945;-甲基-9H-嘌呤-9-乙醇 盐酸盐, 赤-9-（2-羟基-3-壬基）腺嘌呤 盐酸盐
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关于此项目
经验公式（希尔记法）:
C14H23N5O · HCl
化学文摘社编号:
分子量:
313.83
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
EHNA 盐酸盐, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
储存条件
desiccated
溶解性
DMSO: >10 mg/mL
H2O: >10 mg/mL
SMILES字符串
Cl[H].CCCCCC[C@H]([C@H](C)O)n1cnc2c(N)ncnc12
InChI
1S/C14H23N5O.ClH/c1-3-4-5-6-7-11(10(2)20)19-9-18-12-13(15)16-8-17-14(12)19;/h8-11,20H,3-7H2,1-2H3,(H2,15,16,17);1H/t10-,11+;/m0./s1
InChI key
VVDXNJRUNJMYOZ-VZXYPILPSA-N
基因信息
human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
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一般描述
EHNA是一种腺苷脱氨酶抑制剂。具有抗肿瘤作用。
应用
EHNA盐酸盐用于处于微外植体培养基，以检查负责自噬体在轴突中运动的方向和动作。此外，它还用于核苷补充，以抑制脱氧腺苷被酶腺苷酸脱氨酶分解。
生化/生理作用
腺苷脱氨酶抑制剂。
特点和优势
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Dynein-and activity-dependent retrograde transport of autophagosomes in neuronal axons
Katsumata K, et al.
Autophagy, 6(3), 378-385 (2010)
Adenosine deaminase inhibitor EHNA exhibits a potent anticancer effect against malignant pleural mesothelioma
Nakajima Y, et al.
Cellular Physiology and Biochemistry, 35(1), 51-60 (2015)
Enzyme inhibitors. 26. Bridging hydrophobic and hydrophilic regions on adenosine deaminase with some 9-(2-hydroxy-3-alkyl)adenines.
H J Schaeffer et al.
Journal of medicinal chemistry, 17(1), 6-8 (1974-01-01)
Sarah M Bowers et al.
Pediatric rheumatology online journal, 18(1), 54-54 (2020-07-12)
Human adenosine deaminase 2 (ADA2) is an extracellular enzyme that negatively regulates adenosine-mediated cell signaling by converting adenosine to inosine. Altered ADA2 enzyme activity has been associated with some viral infections and rheumatic diseases. The potential utility of ADA2 as
Kai Zhang et al.
Analytical chemistry, 82(8), 3207-3211 (2010-03-30)
A novel strategy for the fabrication of electrochemical aptasensor is proposed in this work, and the strategy has been employed to develop an aptasensor for the assay of adenosine deaminase activity. While a well-designed oligonucleotide containing three functional regions (an
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Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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