E114
EHNA 盐酸盐
≥98% (HPLC), powder, adenosine deaminase inhibitor
别名:
赤-9-氨基-& # 946;-己基-& # 945;-甲基-9H-嘌呤-9-乙醇 盐酸盐, 赤-9-（2-羟基-3-壬基）腺嘌呤 盐酸盐
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关于此项目
经验公式（希尔记法）:
C14H23N5O · HCl
化学文摘社编号:
分子量:
313.83
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
EHNA 盐酸盐, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
储存条件
desiccated
溶解性
DMSO: >10 mg/mL
H2O: >10 mg/mL
SMILES字符串
Cl[H].CCCCCC[C@H]([C@H](C)O)n1cnc2c(N)ncnc12
InChI
1S/C14H23N5O.ClH/c1-3-4-5-6-7-11(10(2)20)19-9-18-12-13(15)16-8-17-14(12)19;/h8-11,20H,3-7H2,1-2H3,(H2,15,16,17);1H/t10-,11+;/m0./s1
InChI key
VVDXNJRUNJMYOZ-VZXYPILPSA-N
基因信息
human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
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一般描述
EHNA是一种腺苷脱氨酶抑制剂。具有抗肿瘤作用。
应用
EHNA盐酸盐用于处于微外植体培养基，以检查负责自噬体在轴突中运动的方向和动作。此外，它还用于核苷补充，以抑制脱氧腺苷被酶腺苷酸脱氨酶分解。
生化/生理作用
腺苷脱氨酶抑制剂。
特点和优势
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Adenosine deaminase inhibitor EHNA exhibits a potent anticancer effect against malignant pleural mesothelioma
Nakajima Y, et al.
Cellular Physiology and Biochemistry, 35(1), 51-60 (2015)
Enzyme inhibitors. 26. Bridging hydrophobic and hydrophilic regions on adenosine deaminase with some 9-(2-hydroxy-3-alkyl)adenines.
H J Schaeffer et al.
Journal of medicinal chemistry, 17(1), 6-8 (1974-01-01)
Sarah M Bowers et al.
Pediatric rheumatology online journal, 18(1), 54-54 (2020-07-12)
Human adenosine deaminase 2 (ADA2) is an extracellular enzyme that negatively regulates adenosine-mediated cell signaling by converting adenosine to inosine. Altered ADA2 enzyme activity has been associated with some viral infections and rheumatic diseases. The potential utility of ADA2 as
Heidi M B Lesscher et al.
Alcoholism, clinical and experimental research, 41(7), 1271-1279 (2017-04-28)
A substantial part of the risk for alcohol use disorder is determined by genetic factors. We previously used chromosome substitution (CSS) mice, to identify a quantitative trait loci (QTL) for alcohol preference on mouse chromosome 2. The aim of this
Dynein-and activity-dependent retrograde transport of autophagosomes in neuronal axons
Katsumata K, et al.
Autophagy, 6(3), 378-385 (2010)
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