Merck
CN

E1257

Sigma-Aldrich

表皮生长因子 来源于鼠颔下腺

lyophilized powder, BioReagent, suitable for cell culture

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别名:
EGF, 表皮细胞生长因子
CAS号:
EC 号:
MDL编号:
NACRES:
NA.32

生物来源

mouse submaxillary glands

质量水平

产品线

BioReagent

检测方案

≥98% (SDS-PAGE)

形式

lyophilized powder

效能

0.02-2.0 ng/mL EC50

包装

pkg of 0.1 mg

储存条件

avoid repeated freeze/thaw cycles

技术

cell culture | mammalian: suitable

杂质

endotoxin, tested

颜色

white

UniProt登记号

储存温度

2-8°C

基因信息

mouse ... Egf(13645)

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一般描述

Epidermal growth factor (EGF) is the member of EGF-like family of growth factors, that binds to EGF receptor. It is majorly expressed in kidney, parotid gland and salivary gland.

应用

Epidermal Growth Factor from murine submaxillary gland has been used
  • in studying its effects on the development of caustic esophageal stricture in rats
  • for preparation of MCF-10A cell line
  • for the culture of primary hair follicle stem cells from arbas cashmere goat (gHFSCs) and adhesion of hair follicles (HF)

生化/生理作用

Epidermal growth factor (EGF) blocks gastric acid and pepsin secretion and increases gastrointestinal cell proliferation. EGF stimulates proliferation and migration in bone marrow stromal cells (BMSC), that gives rise to osteoblasts, chondrocytes and adipocytes. It functions as a strong mitogenic factor for various cultured cells. Mutations in this gene is linked to hypomagnesemia. EGF plays a major role in the maintenance of hair and skin development.

外形

Lyophilized from 0.2 μm filtered solution in ammonium acetate buffer.

制备说明

Purified by gel filtration and ion-exchange chromatography.

分析说明

The biological activity is measured in a proliferation assay using BALB/MK cells.

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


分析证书(COA)

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示例

T1503
货号
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包装规格/数量

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705578-5MG-PW

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Subcellular localization of epidermal growth factor receptor in human submandibular gland
Lantini MS, et al.
Journal of Anatomy, 208(5), 595-599 (2006)
Effects of caffeic acid phenethyl ester and epidermal growth factor on the development of caustic esophageal stricture in rats
Koltuksuz U, et al.
Journal of Pediatric Surgery, 36(10), 1504-1509 (2001)
Epidermal growth factor promotes proliferation of dermal papilla cells via Notch signaling pathway
Zhang H, et al.
Biochimie, 127(21), 10-18 (2016)
Expression of epidermal growth factor in human tissues
Kajikawa K, et al.
Virchows Archiv. A, Pathological Anatomy and Histopathology, 418(1), 27-32 (1991)
High-sensitivity TFA-free LC-MS for profiling histones
You J, et al.
Proteomics, 11(16), 3326-3334 (2011)

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