E1279
Enoximone
solid
别名:
1,3-Dihydro-4-methyl-5-(4-methylthiobenzoyl)-2H-imidazol-2-one
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关于此项目
经验公式（希尔记法）:
C12H12N2O2S
化学文摘社编号:
分子量:
248.30
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.77
表单
solid
质量水平
颜色
light yellow
溶解性
DMSO: soluble 28 mg/mL
SMILES字符串
CSc1ccc(cc1)C(=O)C2=C(C)NC(=O)N2
InChI
1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16)
InChI key
ZJKNESGOIKRXQY-UHFFFAOYSA-N
基因信息
human ... PDE3A(5139), PDE3B(5140)
相关类别
生化/生理作用
Selective phosphodiesterase III (PDE3) inhibitor. Prevents the degradation of cAMP by PDE.
Selective phosphodiesterase III (PDE3) inhibitor. Prevents the degradation of cAMP by PDE. Increased cAMP results in enhanced contractility of the heart.
特点和优势
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
John J O'Sullivan et al.
Transplantation, 85(7), 975-979 (2008-04-15)
The prognosis of acute heart failure is such that many children are considered for transplantation. Recovery of severe heart failure in a proportion of patients diagnosed with either dilated cardiomyopathy or myocarditis is well recognized, and this complicates the assessment
Marko Gujic et al.
American journal of physiology. Heart and circulatory physiology, 294(1), H322-H329 (2007-10-30)
cAMP plays an important role in peripheral chemoreflex function in animals. We tested the hypothesis that the phosphodiesterase inhibitor and inotropic medication enoximone increases peripheral chemoreflex function in humans. In a single-blind, randomized, placebo-controlled crossover study of 15 men, we
Joerg T Fuhrmann et al.
Critical care medicine, 36(8), 2257-2266 (2008-07-31)
Cardiogenic shock is the leading cause of death in patients hospitalized for acute myocardial infarction. The objectives were to investigate the effects of levosimendan, a novel inodilator, compared with the phosphodiesterase-III inhibitor enoximone in refractory cardiogenic shock complicating acute myocardial
M W Vernon et al.
Drugs, 42(6), 997-1017 (1991-12-01)
Enoximone is an imidazolone derivative currently undergoing trials in patients with congestive heart failure refractory to conventional therapy. It is a phosphodiesterase inhibitor with both positive inotropic and vasodilator properties, and is active by both oral and intravenous routes of
Stijn Schauvliege et al.
Veterinary anaesthesia and analgesia, 36(2), 101-109 (2009-02-26)
To investigate the influence of calcium chloride (CaCl(2)) on the cardio-respiratory effects of enoximone in isoflurane anaesthetized ponies. Prospective consecutive experimental trial. Animals Six healthy ponies, weighing 287 +/- 55 kg were included in this study. After sedation (romifidine, 80
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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