E1379
7-乙氧基香豆素
≥99.45% (HPLC), CYP450 substrate, powder
别名:
7-乙氧基-1-苯并吡喃-2-酮
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关于此项目
经验公式(希尔记法):
C11H10O3
化学文摘社编号:
分子量:
190.20
Beilstein:
146200
EC 号:
MDL编号:
UNSPSC代码:
12161501
PubChem化学物质编号:
NACRES:
NA.77
产品名称
7-乙氧基香豆素,
方案
≥99.45% (HPLC)
表单
powder
mp
88-90 °C (lit.)
溶解性
95% ethanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
荧光
λex 323 nm; λem 386 nm
SMILES字符串
CCOc1ccc2C=CC(=O)Oc2c1
InChI
1S/C11H10O3/c1-2-13-9-5-3-8-4-6-11(12)14-10(8)7-9/h3-7H,2H2,1H3
InChI key
LIFAQMGORKPVDH-UHFFFAOYSA-N
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应用
7-乙氧基香豆素已被用于研究重组P450的功能活性。) 它还被用作 体外S-华法林7-羟基化作用和高效液相色谱(HPLC)分析的内标物。
生化/生理作用
7-乙氧基香豆素是细胞色素P450 的一种底物。
CYP2B6 的底物
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Unravelling the molecular determinants of bee sensitivity to neonicotinoid insecticides
Manjon C, et al.
Current Biology, 28(7), 1137-1143 (2018)
Functional characterization of human CYP2C9 allelic variants in COS-7 cells
Du H, et al.
Frontiers in Pharmacology, 7, 98-98 (2016)
Tomohide Uno et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 147(3), 278-285 (2008-02-05)
We indicated that two P450s (1A9 and 1C1) from Japanese eel (Anguilla japonica) metabolized 7-ethoxycoumarin, 7-ethoxyresorufin, and flavanone. At first, we constructed expression vectors for two types of P450 (1A9 and 1C1). The reduced CO-difference spectra of Escherichia coli cells
Wataru Kuki et al.
Nutrition and cancer, 60(3), 368-372 (2008-04-30)
We previously reported that auraptene (7-geranyloxycoumarin; AUR), a coumarin that occurs widely in citrus fruit, has been shown to be a promising cancer-preventive agent in several rodent models. However, its bioavailability and metabolism have not been investigated. In this study
Diansong Zhou et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(7), 1015-1018 (2010-04-13)
Dog CYP2A13 and CYP2A25 were coexpressed with dog NADPH-cytochrome P450 reductase (OR) in baculovirus-infected Sf9 insect cells. CYP2A13 effectively catalyzed 7-ethoxycoumarin (7EC) deethylation and coumarin hydroxylation with apparent K(m) values of 4.8 and 2.1 microM, respectively, similar to those observed
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