E1379
7-乙氧基香豆素
≥99.45% (HPLC), CYP450 substrate, powder
别名:
7-乙氧基-1-苯并吡喃-2-酮
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关于此项目
经验公式（希尔记法）:
C11H10O3
化学文摘社编号:
分子量:
190.20
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
EC Number:
250-429-4
MDL number:
Beilstein/REAXYS Number:
146200
产品名称
7-乙氧基香豆素,
InChI
1S/C11H10O3/c1-2-13-9-5-3-8-4-6-11(12)14-10(8)7-9/h3-7H,2H2,1H3
InChI key
LIFAQMGORKPVDH-UHFFFAOYSA-N
SMILES string
CCOc1ccc2C=CC(=O)Oc2c1
assay
≥99.45% (HPLC)
form
powder
mp
88-90 °C (lit.)
solubility
95% ethanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
fluorescence
λex 323 nm; λem 386 nm
Quality Level
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Application
7-乙氧基香豆素已被用于研究重组P450的功能活性。) 它还被用作 体外S-华法林7-羟基化作用和高效液相色谱（HPLC）分析的内标物。
Biochem/physiol Actions
7-乙氧基香豆素是细胞色素P450 的一种底物。
CYP2B6 的底物
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Du H, et al.
Frontiers in Pharmacology, 7, 98-98 (2016)
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To evaluate the feasibility of using the silkworm as a model animal for screening drug candidates, we examined whether the lethal dose of cytotoxic chemicals in silkworm, Bombyx mori, were consistent with those in mammals, and compared the metabolic pathways
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Drug metabolism and disposition: the biological fate of chemicals, 36(11), 2166-2170 (2008-08-02)
Recently, wild-type and mutant forms of bacterial cytochrome P450 BM3 (CYP102A1) have been found to metabolize various drugs through reactions similar to those catalyzed by human cytochromes P450 (P450s). Therefore, it has been suggested that CYP102A1 may be used to
Ying Zhou et al.
Applied microbiology and biotechnology, 87(2), 647-655 (2010-03-13)
Systematic screening of single-gene knockout collection of Escherichia coli BW25113 (the Keio collection) was performed to select mutants that could enhance the deethylation of 7-ethoxycoumarin catalyzed by CYP154A1. After 96-well plate high-throughput screening followed by test tube assays, four mutants
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