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Merck
CN

E1379

7-乙氧基香豆素

≥99.45% (HPLC), CYP450 substrate, powder

别名:

7-乙氧基-1-苯并吡喃-2-酮

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关于此项目

经验公式(希尔记法):
C11H10O3
化学文摘社编号:
分子量:
190.20
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
EC Number:
250-429-4
MDL number:
Beilstein/REAXYS Number:
146200
Assay:
≥99.45% (HPLC)
Form:
powder
Quality level:
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产品名称

7-乙氧基香豆素,

InChI

1S/C11H10O3/c1-2-13-9-5-3-8-4-6-11(12)14-10(8)7-9/h3-7H,2H2,1H3

InChI key

LIFAQMGORKPVDH-UHFFFAOYSA-N

SMILES string

CCOc1ccc2C=CC(=O)Oc2c1

assay

≥99.45% (HPLC)

form

powder

mp

88-90 °C (lit.)

solubility

95% ethanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

fluorescence

λex 323 nm; λem 386 nm

Quality Level

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Application

7-乙氧基香豆素已被用于研究重组P450的功能活性。) 它还被用作 体外S-华法林7-羟基化作用和高效液相色谱(HPLC)分析的内标物。

Biochem/physiol Actions

7-乙氧基香豆素是细胞色素P450 的一种底物。
CYP2B6 的底物

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Unravelling the molecular determinants of bee sensitivity to neonicotinoid insecticides
Manjon C, et al.
Current Biology, 28(7), 1137-1143 (2018)
Functional characterization of human CYP2C9 allelic variants in COS-7 cells
Du H, et al.
Frontiers in Pharmacology, 7, 98-98 (2016)
Janja Plazar et al.
Toxicology in vitro : an international journal published in association with BIBRA, 22(2), 318-327 (2007-11-06)
Xanthohumol (XN), the principal prenylated flavonoid in the hop plant, Humulus lupulus L., is suggested to have cancer chemo-preventive activities. Its mechanisms of protection have been proposed to be inhibition of metabolic activation, induction of detoxifying enzymes and antioxidant activity.
Diansong Zhou et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(7), 1015-1018 (2010-04-13)
Dog CYP2A13 and CYP2A25 were coexpressed with dog NADPH-cytochrome P450 reductase (OR) in baculovirus-infected Sf9 insect cells. CYP2A13 effectively catalyzed 7-ethoxycoumarin (7EC) deethylation and coumarin hydroxylation with apparent K(m) values of 4.8 and 2.1 microM, respectively, similar to those observed
Yasufumi Fukano et al.
Nanomedicine (London, England), 7(9), 1365-1374 (2012-05-16)
We investigated the heterogeneity of tafluprost metabolism in primary human hepatocytes at a single-cell level by live single-cell mass spectrometry (MS). Picoliter volumes of cytoplasm were analyzed by nano-electrospray ionization MS in order to obtain single-cell metabolite profiles. The subcellular

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