E1383
依托泊苷
95.0-105.0% (anhydrous basis), powder, topoisomerase II inhibitor
别名:
4′-去甲基表鬼臼毒素 -(4,6-O-亚乙基-β-D-吡喃葡萄糖苷), VP-16-213
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关于此项目
产品名称
依托泊苷, synthetic, 95.0-105.0%, powder
biological source
synthetic
Quality Segment
assay
95.0-105.0%
form
powder
color
white to off-white
pKa
9.8
mp
236-251 °C (lit.)
antibiotic activity spectrum
neoplastics
mode of action
DNA synthesis | interferes, enzyme | inhibits
originator
Teva
SMILES string
COc1cc(cc(OC)c1O)[C@H]2[C@@H]3[C@H](COC3=O)[C@H](O[C@@H]4O[C@@H]5CO[C@@H](C)O[C@H]5[C@H](O)[C@H]4O)c6cc7OCOc7cc26
InChI
1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1
InChI key
VJJPUSNTGOMMGY-MRVIYFEKSA-N
Gene Information
human ... ABCB1(5243), CYP3A4(1576), TOP2A(7153), TOP2B(7155)
mouse ... Abcb1a(18671), Abcb1b(18669)
rat ... Top2a(360243)
General description
Application
- 在二甲亚砜（DMSO）中制备药物储备溶液，分析比较 DT40 突变细胞的敏感性
- 培养细胞进行细胞活力测定
- 治疗neuro-2A细胞（脑神经瘤细胞），诱导细胞程序性死亡
Biochem/physiol Actions
Features and Benefits
Packaging
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B - Repr. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges