E1406
恩贝酸
≥98% (HPLC), powder
别名:
2,5-二羟基-3-十一烷基-2,5-环己二烯-1,4-二酮, 恩贝灵, 恩贝酸
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关于此项目
经验公式（希尔记法）:
C17H26O4
化学文摘社编号:
分子量:
294.39
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
208-979-8
MDL number:
产品名称
恩贝酸, ≥98% (HPLC), powder
InChI key
IRSFLDGTOHBADP-UHFFFAOYSA-N
InChI
1S/C17H26O4/c1-2-3-4-5-6-7-8-9-10-11-13-16(20)14(18)12-15(19)17(13)21/h12,18,21H,2-11H2,1H3
SMILES string
CCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O
assay
≥98% (HPLC)
form
powder
solubility
DMSO: >10 mg/mL
H2O: insoluble
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
parasites
mode of action
DNA synthesis | interferes
Quality Level
Gene Information
human ... XIAP(331)
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相关类别
Application
使用恩贝酸：
- 研究其对活化T细胞(NFATc1)荧光素酶活性的核因子kB配体(RANKL)诱导的核因子的受体激活剂的影响
- 研究其在介导帕金森病(PD)机制中的作用′
- 治疗全鼠胚胎，以确定其对X连锁抑制细胞凋亡蛋白(XIAP)活性的影响
Biochem/physiol Actions
恩贝酸具有抗氧化、线粒体解耦联和抗生育特性。它还具有抗糖尿病、抗惊厥、抗焦虑和抗微生物活性等作用。恩贝酸是一种有效的神经保护剂，也可作为脑卒中的辅助治疗。
恩贝酸（Embelin）是XIAP（X连锁凋亡抑制蛋白）的抑制剂；体内抗肿瘤和抗炎活性。
General description
恩贝酸是一种天然的苯醌衍生物，最早从白花酸滕果植物中提取。它在结构上类似于泛醌。
signalword
Warning
hcodes
pcodes
Hazard Classifications
Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Boreddy Shivanandappa Thippeswamy et al.
European journal of pharmacology, 654(1), 100-105 (2010-12-28)
The aim of the present study is to evaluate the effect of embelin isolated from Embelia ribes on acetic acid induced colitis in rats. Experimental animals received embelin (25 and 50 mg/kg, p.o.) and sulfasalazine (100mg/kg, p.o.) for five consecutive
Uday P Kundap et al.
Frontiers in pharmacology, 8, 76-76 (2017-03-16)
A Central nervous system (CNS) disease is the one which affects either the spinal cord or brain and causing neurological or psychiatric complications. During the nineteenth century, modern medicines have occupied the therapy for many ailments and are widely used
Feng Li et al.
Biomacromolecules, 11(10), 2610-2620 (2010-09-02)
The objective of this study was to design lipopolymers for hydrophobic drug delivery. Poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene carbonate-graft-dodecanol) (PEG-PCD) lipopolymers were synthesized and characterized by (1)H NMR, FT-IR, GPC, and DSC. The critical micelle concentration (CMC) of PEG-PCD micelles was around 10(-8)
Sang-Yoon Park et al.
Journal of pharmacological sciences, 121(3), 192-199 (2013-03-22)
Aggressive tumor growth and diffuse tissue invasion are hallmarks of malignant glioma. Embelin is an active compound identified as a novel XIAP inhibitor from the Embelia ribes that exhibits various medicinal effects including anti-inflammatory and anti-cancer activities. In the present
G Kalyan Kumar et al.
European journal of pharmacology, 662(1-3), 63-69 (2011-05-10)
Tumor necrosis factor-α (TNF-α) is known to play a crucial role in the pathogenesis of psoriasis. The present study was designed to investigate the effects of embelin on lipopolysachharide induced TNF-α production in mice and in human keratinocytes in vitro
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