E1532
Monoclonal Anti-E2F6 antibody produced in mouse
~1.0 mg/mL, clone TFE61, purified immunoglobulin, buffered aqueous solution
别名:
Anti-E2F transcription factor 6, Anti-E2F-6
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
TFE61, monoclonal
Application:
ELISA (i), ICC, WB
Citations:
7
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
TFE61, monoclonal
form
buffered aqueous solution
mol wt
antigen ~35 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
immunocytochemistry: suitable, indirect ELISA: suitable, western blot: 2-4 μg/mL using HeLa nuclear cell extract
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... E2F6(1876)
General description
E2F6 transcription factor belongs to the third class of E2Fs. The E2F transcription factors are a family of genes that play critical roles in regulation of cellular proliferation and differentiation.
Immunogen
recombinant human E2F6 protein
Application
Monoclonal Anti-E2F6 antibody produced in mouse is suitable for immunocytochemistry and indirect ELISA. It is also suitable for western blotting at a working concentration of 2-4μg/mL using HeLa nuclear cell extract.
Biochem/physiol Actions
The third class of E2Fs lacks both the retinoblastoma protein binding and transcriptional activation domain, and is an active repressor of transcription. The activity of E2F6 is mediated through its recruitment of polycomb transcriptional repressor complexes in a histone methylation independent manner. E2F6 associates with E2F target genes that are activated at G1/S phase. Its repression activity during the S-phase distinguishes G1/S and G2/M transcription during cell cycle. It may be involved in various cancerous processes.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
wgk
WGK 1
存储类别
12 - Non Combustible Liquids
法规信息
常规特殊物品
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相关内容
Instructions
Phillip J Iaquinta et al.
Current opinion in cell biology, 19(6), 649-657 (2007-11-23)
The E2F transcription factors are critical regulators of genes required for appropriate progression through the cell cycle, and in special circumstances they can also promote the expression of another class of genes that function in the apoptotic program. Since E2Fs
J M Trimarchi et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(6), 2850-2855 (1998-04-18)
The E2F family of proteins is required to establish the correct cell-cycle-dependent transcription of genes that direct the process of cell division. All previously identified E2F proteins can act in a similar manner; depending on whether or not they are
Gwen MacDonald et al.
Breast cancer research : BCR, 9(4), R49-R49 (2007-08-01)
Decreased transcription of the BRCA1 gene has previously been observed to occur in sporadic breast tumours, making elucidation of the mechanisms regulating the expression of this gene important for our understanding of the etiology of the disease. Transcriptional elements involved
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| E1532-200UL | 04061836265137 |