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Merck
CN

E1753

(−)-表儿茶素

≥90% (HPLC)

别名:

(-)-顺式-3,3′,4′,5,7-五羟基黄烷, (2R,3R)-2-(3,4-二羟基苯基)-3,4-二氢-1(2H)-苯并吡喃-3,5,7-三醇

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关于此项目

经验公式（希尔记法）:
C15H14O6
化学文摘社编号:
490-46-0
分子量:
290.27
UNSPSC Code:
12352205
NACRES:
NA.77
PubChem Substance ID:
24894431
EC Number:
207-710-1
Beilstein/REAXYS Number:
92760
MDL number:
MFCD00075648

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产品名称

(−)-表儿茶素, ≥90% (HPLC)

InChI key

PFTAWBLQPZVEMU-UKRRQHHQSA-N

InChI

1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15-/m1/s1

SMILES string

O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3ccc(O)c(O)c3

assay

≥90% (HPLC)

form

powder

mp

240 °C (dec.) (lit.)

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

Quality Level

200

Gene Information

human ... BACE1(23621), CYP1A2(1544)

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相关类别

Application

(−)-表儿茶素(EC)已用于：
  • 在体内（高脂喂养小鼠）和体外（HepG2细胞）研究中，作为抗氧化剂下调烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶水平和提高胰岛素敏感性。
  • 研究其对边缘高血压大鼠(BHR)模型血压、一氧化氮合酶(NOS)活性和类焦虑行为的影响
  • 使用氧化应激参数检测其对游泳训练中的中年小鼠海马体神经元存活情况的影响。
  • 研究其在黑巧克力中的抗氧化性
  • 作为多酚分析的特征化合物

Biochem/physiol Actions

表儿茶素可增强心力衰竭患者的骨骼肌结构，最大限度降低心脏代谢风险。可用于治疗肌肉减少症。表儿茶素减少肌肉生长抑制素和 β-半乳糖苷酶，提高肌肉生长标志物水平。

General description

(−)-表儿茶素(EC)属于黄烷醇类化合物，在可可和可可产品中大量存在。表儿茶素的化学结构由1个4-羟基含氧杂环连接2个苯环组成。

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
WXBF5883V
WXBF3597V
BCCJ9702
BCCJ1391
BCCD3979

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Joseph Shay et al.
Oxidative medicine and cellular longevity, 2015, 181260-181260 (2015-07-17)
With recent insight into the mechanisms involved in diseases, such as cardiovascular disease, cancer, stroke, neurodegenerative diseases, and diabetes, more efficient modes of treatment are now being assessed. Traditional medicine including the use of natural products is widely practiced around
S Abhijit et al.
Experimental gerontology, 101, 101-112 (2017-11-28)
The present study explored the effects of swimming training and grape seed proanthocyanidin extract (GSPE) on neuronal survival in the hippocampus (HC) of middle-aged rats along with oxidative stress (OS) parameters. Further, the bioavailability of the GSPE, catechin, epicatechin and
Michal Kluknavsky et al.
Antioxidants (Basel, Switzerland), 9(2) (2020-01-26)
This study investigated the effects of (-)-epicatechin (Epi) in young male borderline hypertensive rats (BHR) during two weeks of treatment (Epi group, 100 mg/kg/day p.o.) and two weeks post treatment (PE group). Epi reduced blood pressure (BP), which persisted for
Effect of dark chocolate on plasma epicatechin levels, DNA resistance to oxidative stress and total antioxidant activity in healthy subjects
Spadafranca A, et al.
The British Journal of Nutrition, 103(7), 1008-1014 (2010)
Effects of (-)-epicatechin on molecular modulators of skeletal muscle growth and differentiation
Gutierrez-Salmean G, et al.
The Journal of Nutritional Biochemistry, 25(1), 91-94 (2014)
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