E1896
Etazolate hydrochloride
solid
别名:
1-Ethyl-4-[(1-methylethylidene)hydrazino]1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester hydrochloride, SQ 20009
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关于此项目
经验公式（希尔记法）:
C14H18N5O2 · HCl
化学文摘社编号:
分子量:
324.79
UNSPSC Code:
41106305
PubChem Substance ID:
MDL number:
产品名称
Etazolate hydrochloride, solid
InChI
1S/C14H19N5O2.ClH/c1-5-19-13-10(8-16-19)12(18-17-9(3)4)11(7-15-13)14(20)21-6-2;/h7-8H,5-6H2,1-4H3,(H,15,18);1H
SMILES string
Cl.CCOC(=O)c1cnc2n(CC)ncc2c1N\N=C(\C)C
InChI key
GQJUGJHJUZSJLZ-UHFFFAOYSA-N
assay
≥98% (TLC)
form
solid
color
white
mp
193-194 °C
solubility
H2O: >20 mg/mL (Solutions should be freshly prepared.)
storage temp.
room temp
Gene Information
human ... GABRB3(2562), PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
Biochem/physiol Actions
Selective inhibitor of cAMP-specific phosphodiesterase.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
C Tomes et al.
Cellular signalling, 5(5), 615-621 (1993-09-01)
The effect of 17 inhibitors of cyclic nucleotide phosphodiesterases (PDEs) was assayed on cAMP binding activity of Mucor rouxii protein kinase A (PKA), on PKA activity in the absence of cAMP and on free catalytic subunit (C) activity. Isobutylmethylxanthine (IBMX)
D M Barnes et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 3(4), 762-772 (1983-04-01)
The actions of etazolate (SQ20009) on cultured cortical neurons have been examined in electrophysiological experiments and in receptor binding studies. Etazolate (0.3 to 100 microM) prolongs the duration of spontaneously occurring IPSPs. Higher concentrations of etazolate produce an increase in
M Nielsen et al.
Biochemical pharmacology, 34(20), 3633-3642 (1985-10-15)
[35S]t-Butylbicyclophosphorothionate ([35S]TBPS), a bicyclic cage convulsant, binds to the anion gating mechanism of the GABA/benzodiazepine receptor chloride channel complex. Using a carefully calibrated radiation inactivation technique, the molecular weight of [35S]TBPS binding complexes from frozen rat cerebral cortex was estimated
P A Borea et al.
Brain research, 280(2), 383-386 (1983-12-05)
Flunitrazepam, a benzodiazepine agonist increases, and DMCM, an inverse agonist decreases the stimulation by etazolate or pentobarbital of [3H] muscimol binding to membranes of rat cerebral cortex. Ro 15-1788 has no marked effects but antagonizes the action of both flunitrazepam
W H Curley et al.
The Journal of pharmacology and experimental therapeutics, 228(3), 656-661 (1984-03-01)
This study was designed to determine whether cholinergic drug interaction with cyclic (c) AMP phosphodiesterase (PDE) might account for part of the effects of this class of drugs at the neuromuscular junction. The activity levels of both high- and low-affinity
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