E2634
Ergosta-5,7,9（11），22-丁烯--3β-醇
~96% (HPLC)
别名:
脱氢麦角固醇
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关于此项目
经验公式（希尔记法）:
C28H42O
化学文摘社编号:
分子量:
394.63
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
~96% (HPLC)
Quality level:
assay
~96% (HPLC)
Quality Level
storage temp.
−20°C
SMILES string
[H][C@@]1(CC[C@@]2([H])C3=CC=C4C[C@@H](O)CC[C@]4(C)C3=CC[C@]12C)[C@H](C)\C=C\[C@H](C)C(C)C
InChI
1S/C28H42O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h7-10,14,18-20,22,24-25,29H,11-13,15-17H2,1-6H3/b8-7+/t19-,20+,22-,24+,25-,27-,28+/m0/s1
InChI key
QSVJYFLQYMVBDR-CMNOFMQQSA-N
General description
Ergosta-5,7,9（11）,22-tetraen-3β-ol 是麦角固醇的类似物。它由甾体环系统中的三个共轭双键组成。Ergosta-5,7,9（11）,22-tetraen-3β-ol 具有抗炎特性。它用作胆固醇报告物。
Application
Ergosta-5,7,9（11）,22-tetraen-3β-ol 已用于检查卵磷脂：胆固醇酰基转移酶（LCAT）的酰基转移酶活性。它也已经用于脂质体的制备。
荧光胆固醇类似物，可用作膜研究的探针。
signalword
Warning
hcodes
pcodes
Hazard Classifications
Carc. 2 - STOT RE 2
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
易制毒化学品（2类）
此项目有
Dehydroergosterol as an Analogue for Cholesterol: Why It Mimics Cholesterol So Well or Does It?
Pourmousa M, et al.
The Journal of Physical Chemistry B, 118(26), 7345-7357 (2014)
Brad Chazotte
Cold Spring Harbor protocols, 2011(5), pdb-pdb (2011-05-04)
Cholesterol, an essential component of most cellular membranes, is present in the plasma membrane and is enriched within lipid rafts. It is, however, virtually absent from the mitochondrial inner membrane, and there is little within the endoplasmic reticulum. Dehydroergosterol (DHE)
Daniel Wüstner et al.
Histochemistry and cell biology, 130(5), 891-908 (2008-09-13)
Distribution and dynamics of cholesterol in the plasma membrane as well as internalization pathways for sterol from the cell surface are of great cell biological interest. Here, UV-sensitive wide field microscopy of the intrinsically fluorescent sterols, dehydroergosterol (DHE) and cholestatrienol
Fischer, R.T., et al.
J. Biol. Physics, 13, 13-13 (1985)
Peter Kohut et al.
Biochemical and biophysical research communications, 404(1), 233-238 (2010-11-30)
Uptake of external sterols in the yeast Saccharomyces cerevisiae is a multistep process limited to anaerobiosis or heme deficiency. It includes crossing the cell wall, insertion of sterol molecules into plasma membrane and their internalization and integration into intracellular membranes.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| E2634-50MG | 04061832856407 |
| E2634-5MG | 04061833602850 |
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