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E5008

[D-Ala²]-Leucine enkephalin

Name: [<SC>D</SC>-Ala<SUP>2</SUP>]-Leucine enkephalin
Brand: SIGMA

≥97% (HPLC), suitable for ligand binding assays

别名:

Tyr-D-Ala-Gly-Phe-Leu

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关于此项目

经验公式（希尔记法）:

C₂₉H₃₉N₅O₇

化学文摘社编号:

64963-01-5

分子量:

569.65

NACRES:

NA.26

PubChem Substance ID:

24894597

UNSPSC Code:

12352209

EC Number:

265-291-0

MDL number:

MFCD00076409

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属性

产品名称

[D-Ala²]-Leucine enkephalin, ≥97% (HPLC)

Quality Level

200

assay

≥97% (HPLC)

form

powder

technique(s)

ligand binding assay: suitable

color

white

storage temp.

−20°C

SMILES string

CC(C)CC(NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)C(C)NC(=O)C(N)Cc2ccc(O)cc2)C(O)=O

InChI

1S/C29H39N5O7/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20/h4-12,17-18,22-24,35H,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41)

InChI key

ZHUJMSMQIPIPTF-UHFFFAOYSA-N

说明

Biochem/physiol Actions

The Enkephalin amid peptide [D-Ala2]-Leucine enkephalin ((DADLE), a delta opioid agonist, is a degradation resistant long-acting Leu-enkephalin analog used to study the signaling pathway of delta opioid receptors.

Other Notes

Potent, long-acting Leu-enkephalin analog that is resistant to enzymatic degradation

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000531334

0000445691

0000339074

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Agonist activation of p42 and p44 mitogen-activated protein kinases following expression of the mouse delta opioid receptor in Rat-1 fibroblasts: effects of receptor expression levels and comparisons with G-protein activation.

A R Burt et al.

The Biochemical journal, 320 ( Pt 1), 227-235 (1996-11-15)

Rat-1 fibroblasts were transfected with a cDNA encoding the mouse delta opioid receptor. Two separate clones, D2 (which expressed some 6 pmol of the receptor/mg of membrane protein) and DOE (which expressed some 0.2 pmol/mg of membrane protein), were examined

Leucine enkephalin effects on paracellular and transcellular permeation pathways across brain microvessel endothelial cell monolayers.

S E Thompson et al.

Journal of cardiovascular pharmacology, 24(5), 818-825 (1994-11-01)

Leucine enkephalin (YGGFL) effects on markers for transcellular and paracellular permeation across the blood-brain barrier (BBB) were investigated in vitro with bovine brain microvessel endothelial cell (BMEC) monolayers in primary culture. Intact YGGFL, but not metabolites of YGGFL, stimulated BMEC

Activation of mu- and delta-opioid receptors causes presynaptic inhibition of glutamatergic excitation in neocortical neurons.

A M Ostermeier et al.

Anesthesiology, 93(4), 1053-1063 (2000-10-06)

The mechanism underlying the depressant effect of opioids on neuronal activity within the neocortex is still not clear. Three modes of action have been suggested: (1) inhibition by activation of postsynaptic potassium channels, (2) interaction with postsynaptic glutamate receptors, and

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货号	GTIN
E5008-5MG	04061832820262