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Merck
CN

E5406

爱普杷嗪 盐酸盐

≥98% (HPLC), butyrylcholinesterase inhibitor, powder

别名:

10-(2-二乙氨基丙基)吩噻嗪, 10-[2-(二乙氨基)丙基]吩噻嗪 盐酸盐, 乙丙嗪, 二乙异丙嗪 盐酸盐

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关于此项目

经验公式（希尔记法）:
C19H24N2S · HCl
化学文摘社编号:
1094-08-2
分子量:
348.93
NACRES:
NA.77
PubChem Substance ID:
329799070
UNSPSC Code:
12352200
EC Number:
214-134-4
MDL number:
MFCD00012653

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产品名称

爱普杷嗪 盐酸盐, ≥98% (HPLC), powder

InChI

1S/C19H24N2S.ClH/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21;/h6-13,15H,4-5,14H2,1-3H3;1H

InChI key

VXPCQISYVPFYRK-UHFFFAOYSA-N

SMILES string

Cl[H].CCN(CC)C(C)CN1c2ccccc2Sc3ccccc13

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

DMSO: >5 mg/mL at ~60 °C, clear

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... CHRM1(1128)

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相关类别

Biochem/physiol Actions

爱普杷嗪盐酸盐是一种丁酰胆碱酯酶的抑制剂；抗帕金森症药物
爱普杷嗪盐酸盐是一种丁酰胆碱酯酶的抑制剂；抗帕金森症药物。它可以减轻帕金森症的典型症状，即锥体外系副反应；还可以减轻小鼠的热痛觉过敏症状。

Features and Benefits

该化合物收录于受体分类和信号转导手册的《乙酰胆碱合成与代谢》页面。想要浏览手册的其他页面， 请单击此处。

General description

盐酸乙氧丙嗪具有抗胆碱能、抗组胺和抗肾上腺素能特性。

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000485583
0000485582
0000485582
0000485583
0000352042

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Min Fu et al.
Molecular biology of the cell, 24(8), 1153-1162 (2013-02-22)
Glycoprotein 78 (Gp78) is a critical E3 ubiquitin ligase in endoplasmic reticulum-associated degradation. Overexpression of Flag-tagged Gp78 (Flag-gp78), but not Flag-gp78 mutated in its RING-finger domain (Flag-RINGmut) with deficient ubiquitin ligase activity, induces mitochondrial fragmentation and ubiquitination and proteasome-dependent degradation
Katherine C M Chew et al.
PloS one, 6(5), e19720-e19720 (2011-06-01)
Mutations in the parkin gene, which encodes a ubiquitin ligase (E3), are a major cause of autosomal recessive parkinsonism. Although parkin-mediated ubiquitination was initially linked to protein degradation, accumulating evidence suggests that the enzyme is capable of catalyzing multiple forms
Transition Metal Complexes of Ethopropazine: Synthesis and Characterization
Debbeti V, et al.
American Journal of Chemistry, 2(6), 294-298 (2012)
Joe H Pogson et al.
PLoS genetics, 10(11), e1004815-e1004815 (2014-11-21)
Mutations in PINK1, a mitochondrially targeted serine/threonine kinase, cause autosomal recessive Parkinson's disease (PD). Substantial evidence indicates that PINK1 acts with another PD gene, parkin, to regulate mitochondrial morphology and mitophagy. However, loss of PINK1 also causes complex I (CI)
Derek Narendra et al.
The Journal of cell biology, 183(5), 795-803 (2008-11-26)
Loss-of-function mutations in Park2, the gene coding for the ubiquitin ligase Parkin, are a significant cause of early onset Parkinson's disease. Although the role of Parkin in neuron maintenance is unknown, recent work has linked Parkin to the regulation of
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商品

Acetylcholine Synthesis and Metabolism

Acetylcholine is synthesized from acetyl coenzyme A and choline by the enzyme choline acetyltransferase. In addition to its synthesis in the liver, choline employed in acetylcholine production is derived from dietary sources.

乙酰胆碱合成及代谢

乙酰胆碱由胆碱乙酰转移酶从乙酰辅酶A和胆碱合成而来。用于生成乙酰胆碱的胆碱除了在肝脏中合成外，还来源于膳食。

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