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E5406

爱普杷嗪盐酸盐

Name: 爱普杷嗪 盐酸盐
Brand: SIGMA

≥98% (HPLC), butyrylcholinesterase inhibitor, powder

别名:

10-(2-二乙氨基丙基)吩噻嗪, 10-[2-(二乙氨基)丙基]吩噻嗪盐酸盐, 乙丙嗪, 二乙异丙嗪盐酸盐

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关于此项目

经验公式（希尔记法）:

C₁₉H₂₄N₂S · HCl

化学文摘社编号:

1094-08-2

分子量:

348.93

NACRES:

NA.77

PubChem Substance ID:

329799070

UNSPSC Code:

12352200

EC Number:

214-134-4

MDL number:

MFCD00012653

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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产品名称

爱普杷嗪盐酸盐, ≥98% (HPLC), powder

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

DMSO: >5 mg/mL at ~60 °C, clear

storage temp.

2-8°C

SMILES string

Cl[H].CCN(CC)C(C)CN1c2ccccc2Sc3ccccc13

InChI

1S/C19H24N2S.ClH/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21;/h6-13,15H,4-5,14H2,1-3H3;1H

InChI key

VXPCQISYVPFYRK-UHFFFAOYSA-N

Gene Information

human ... CHRM1(1128)

General description

盐酸乙氧丙嗪具有抗胆碱能、抗组胺和抗肾上腺素能特性。

Biochem/physiol Actions

爱普杷嗪盐酸盐是一种丁酰胆碱酯酶的抑制剂；抗帕金森症药物

爱普杷嗪盐酸盐是一种丁酰胆碱酯酶的抑制剂；抗帕金森症药物。它可以减轻帕金森症的典型症状，即锥体外系副反应；还可以减轻小鼠的热痛觉过敏症状。

Features and Benefits

该化合物收录于受体分类和信号转导手册的《乙酰胆碱合成与代谢》页面。想要浏览手册的其他页面，请单击此处。

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy.

Nickie C Chan et al.

Human molecular genetics, 20(9), 1726-1737 (2011-02-08)

Parkin, an E3 ubiquitin ligase implicated in Parkinson's disease, promotes degradation of dysfunctional mitochondria by autophagy. Using proteomic and cellular approaches, we show that upon translocation to mitochondria, Parkin activates the ubiquitin-proteasome system (UPS) for widespread degradation of outer membrane

Regulation of mitophagy by the Gp78 E3 ubiquitin ligase.

Min Fu et al.

Molecular biology of the cell, 24(8), 1153-1162 (2013-02-22)

Glycoprotein 78 (Gp78) is a critical E3 ubiquitin ligase in endoplasmic reticulum-associated degradation. Overexpression of Flag-tagged Gp78 (Flag-gp78), but not Flag-gp78 mutated in its RING-finger domain (Flag-RINGmut) with deficient ubiquitin ligase activity, induces mitochondrial fragmentation and ubiquitination and proteasome-dependent degradation

Proteasome inhibition promotes Parkin-Ubc13 interaction and lysine 63-linked ubiquitination.

Grace G Y Lim et al.

PloS one, 8(9), e73235-e73235 (2013-09-12)

Disruption of the ubiquitin-proteasome system, which normally identifies and degrades unwanted intracellular proteins, is thought to underlie neurodegeneration. Supporting this, mutations of Parkin, a ubiquitin ligase, are associated with autosomal recessive parkinsonism. Remarkably, Parkin can protect neurons against a wide

Parkin mediates apparent E2-independent monoubiquitination in vitro and contains an intrinsic activity that catalyzes polyubiquitination.

Katherine C M Chew et al.

PloS one, 6(5), e19720-e19720 (2011-06-01)

Mutations in the parkin gene, which encodes a ubiquitin ligase (E3), are a major cause of autosomal recessive parkinsonism. Although parkin-mediated ubiquitination was initially linked to protein degradation, accumulating evidence suggests that the enzyme is capable of catalyzing multiple forms

Transition Metal Complexes of Ethopropazine: Synthesis and Characterization

Debbeti V, et al.

American Journal of Chemistry, 2(6), 294-298 (2012)

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Acetylcholine Synthesis and Metabolism

Acetylcholine is synthesized from acetyl coenzyme A and choline by the enzyme choline acetyltransferase. In addition to its synthesis in the liver, choline employed in acetylcholine production is derived from dietary sources.

乙酰胆碱合成及代谢

乙酰胆碱由胆碱乙酰转移酶从乙酰辅酶A和胆碱合成而来。用于生成乙酰胆碱的胆碱除了在肝脏中合成外，还来源于膳食。

全球贸易项目编号

货号	GTIN
E5406-250MG	04061833604304
E5406-50MG	04061833604311

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