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Merck
CN

E5406

Sigma-Aldrich

爱普杷嗪 盐酸盐

≥98% (HPLC), butyrylcholinesterase inhibitor, powder

别名:

10-(2-二乙氨基丙基)吩噻嗪, 10-[2-(二乙氨基)丙基]吩噻嗪 盐酸盐, 乙丙嗪, 二乙异丙嗪 盐酸盐

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关于此项目

经验公式（希尔记法）:
C19H24N2S · HCl
CAS Number:
1094-08-2
分子量:
348.93
EC 号:
214-134-4
MDL编号:
MFCD00012653
UNSPSC代码:
12352200
PubChem化学物质编号:
329799070
NACRES:
NA.77

主要文件

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Product Name

爱普杷嗪 盐酸盐, ≥98% (HPLC), powder

质量水平

100

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

white

溶解性

DMSO: >5 mg/mL at ~60 °C, clear

储存温度

2-8°C

SMILES字符串

Cl[H].CCN(CC)C(C)CN1c2ccccc2Sc3ccccc13

InChI

1S/C19H24N2S.ClH/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21;/h6-13,15H,4-5,14H2,1-3H3;1H

InChI key

VXPCQISYVPFYRK-UHFFFAOYSA-N

基因信息

human ... CHRM1(1128)

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相关类别

一般描述

盐酸乙氧丙嗪具有抗胆碱能、抗组胺和抗肾上腺素能特性。

生化/生理作用

爱普杷嗪盐酸盐是一种丁酰胆碱酯酶的抑制剂；抗帕金森症药物
爱普杷嗪盐酸盐是一种丁酰胆碱酯酶的抑制剂；抗帕金森症药物。它可以减轻帕金森症的典型症状，即锥体外系副反应；还可以减轻小鼠的热痛觉过敏症状。

特点和优势

该化合物收录于受体分类和信号转导手册的《乙酰胆碱合成与代谢》页面。想要浏览手册的其他页面， 请单击此处。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000352042
0000352042
0000235829
0000235829
0000134513

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Nickie C Chan et al.
Human molecular genetics, 20(9), 1726-1737 (2011-02-08)
Parkin, an E3 ubiquitin ligase implicated in Parkinson's disease, promotes degradation of dysfunctional mitochondria by autophagy. Using proteomic and cellular approaches, we show that upon translocation to mitochondria, Parkin activates the ubiquitin-proteasome system (UPS) for widespread degradation of outer membrane
Min Fu et al.
Molecular biology of the cell, 24(8), 1153-1162 (2013-02-22)
Glycoprotein 78 (Gp78) is a critical E3 ubiquitin ligase in endoplasmic reticulum-associated degradation. Overexpression of Flag-tagged Gp78 (Flag-gp78), but not Flag-gp78 mutated in its RING-finger domain (Flag-RINGmut) with deficient ubiquitin ligase activity, induces mitochondrial fragmentation and ubiquitination and proteasome-dependent degradation
Grace G Y Lim et al.
PloS one, 8(9), e73235-e73235 (2013-09-12)
Disruption of the ubiquitin-proteasome system, which normally identifies and degrades unwanted intracellular proteins, is thought to underlie neurodegeneration. Supporting this, mutations of Parkin, a ubiquitin ligase, are associated with autosomal recessive parkinsonism. Remarkably, Parkin can protect neurons against a wide
Kei Okatsu et al.
Nature communications, 3, 1016-1016 (2012-08-23)
Dysfunction of PINK1, a mitochondrial Ser/Thr kinase, causes familial Parkinson's disease (PD). Recent studies have revealed that PINK1 is rapidly degraded in healthy mitochondria but accumulates on the membrane potential (ΔΨm)-deficient mitochondria, where it recruits another familial PD gene product
Katherine C M Chew et al.
PloS one, 6(5), e19720-e19720 (2011-06-01)
Mutations in the parkin gene, which encodes a ubiquitin ligase (E3), are a major cause of autosomal recessive parkinsonism. Although parkin-mediated ubiquitination was initially linked to protein degradation, accumulating evidence suggests that the enzyme is capable of catalyzing multiple forms
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商品

乙酰胆碱合成及代谢

乙酰胆碱由胆碱乙酰转移酶从乙酰辅酶A和胆碱合成而来。用于生成乙酰胆碱的胆碱除了在肝脏中合成外，还来源于膳食。

Acetylcholine Synthesis and Metabolism

Acetylcholine is synthesized from acetyl coenzyme A and choline by the enzyme choline acetyltransferase. In addition to its synthesis in the liver, choline employed in acetylcholine production is derived from dietary sources.

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