E5757
Methionine Enkephalin-Arg-Phe acetate salt hydrate
≥97% (HPLC)
别名:
MERF, Tyr-Gly-Gly-Phe-Met-Arg-Phe
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关于此项目
经验公式（希尔记法）:
C42H56N10O9S · xC2H4O2 · yH2O
分子量:
877.02 (anhydrous free base basis)
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Assay:
≥97% (HPLC)
assay
≥97% (HPLC)
storage temp.
−20°C
SMILES string
O.CC(O)=O.CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3ccccc3)C(O)=O
InChI
1S/C42H56N10O9S.C2H4O2.H2O/c1-62-20-18-32(39(58)50-31(13-8-19-46-42(44)45)38(57)52-34(41(60)61)23-27-11-6-3-7-12-27)51-40(59)33(22-26-9-4-2-5-10-26)49-36(55)25-47-35(54)24-48-37(56)30(43)21-28-14-16-29(53)17-15-28;1-2(3)4;/h2-7,9-12,14-17,30-34,53H,8,13,18-25,43H2,1H3,(H,47,54)(H,48,56)(H,49,55)(H,50,58)(H,51,59)(H,52,57)(H,60,61)(H4,44,45,46);1H3,(H,3,4);1H2/t30-,31-,32-,33-,34-;;/m0../s1
InChI key
WOWLRTTTXHINBL-AVEXNAMASA-N
Biochem/physiol Actions
Endogenous opioid heptapeptide that is an agonist at μ, δ, and κ receptors; also binds to σ2 receptors.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
M Wollemann et al.
Acta biologica Hungarica, 50(1-3), 297-307 (1999-11-26)
In previous communications [4, 38] we published that [3H]Met-enkephalin-Arg6-Phe7 (MERF) binds to opioid (kappa2 and delta) and sigma2 sites in frog and rat brain membrane preparations, however no binding to kappa1 sites could be established. In the present paper we
K W Kim et al.
Life sciences, 67(1), 61-71 (2000-07-15)
This study was undertaken to examine the receptor selectivity of Met-enkephalin-Arg6-Phe7 (MERF) employing radioreceptor binding assays in human cerebral cortex membranes, and to elucidate the responsible receptors that mediate the regulatory action of MERF on high (20 mM) K+-stimulated release
C H McIntosh et al.
The American journal of physiology, 259(6 Pt 1), G922-G927 (1990-12-01)
The opioid peptides are potent inhibitors of gastric somatostatin-like immunoreactivity (SLI) secretion from the isolated perfused rat stomach. In addition, inhibition of SLI secretion induced by vagal stimulation is partially blocked by naloxone, indicating that endogenously released opioid peptides probably