Merck
CN

E6005

Sigma-Aldrich

乙硫磷酰胺

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别名:
2-乙基-4-吡啶羧基硫代酰胺
Empirical Formula (Hill Notation):
C8H10N2S
CAS号:
分子量:
166.24
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.26

检测方案

≥98.0%

质量水平

形式

powder

technique(s)

ligand binding assay: suitable

颜色

yellow

储存温度

2-8°C

SMILES string

CCc1cc(ccn1)C(N)=S

InChI

1S/C8H10N2S/c1-2-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11)

InChI key

AEOCXXJPGCBFJA-UHFFFAOYSA-N

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此商品
SMB00387A105793829
Ethionamide

Sigma-Aldrich

E6005

乙硫磷酰胺

-
Prothionamide ≥99% (HPLC)

Sigma-Aldrich

SMB00387

Prothionamide

-
L-Tyrosine BioUltra, ≥99.0% (NT)

Sigma-Aldrich

93829

L-酪氨酸

Premium Grade
form

powder

form

powder

form

powder

form

powder or crystals

technique(s)

ligand binding assay: suitable

technique(s)

-

technique(s)

ligand binding assay: suitable

technique(s)

ligand binding assay: suitable

color

yellow

color

yellow

color

white to off-white

color

white

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

一般描述

乙硫异烟胺 (ETA,ETH) 是一种硫代酰胺 ,是一种抗结核药,在其他药物无效时,可作为二线治疗药物用于治疗结核病。 ETA 的结构与异烟肼相似。

应用

乙硫异烟胺用于抗菌剂 和测试化合物对 结核分枝杆菌的效价测定

生化/生理作用

乙硫异烟胺用作抗结核抗生素和甲状腺功能减退的诱导剂。

象形图

Exclamation markHealth hazard

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


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利福平

A E DeBarber et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(17), 9677-9682 (2000-08-16)
Ethionamide (ETA) is an important component of second-line therapy for the treatment of multidrug-resistant tuberculosis. Synthesis of radiolabeled ETA and an examination of drug metabolites formed by whole cells of Mycobacterium tuberculosis (MTb) have allowed us to demonstrate that ETA
Liang-Chun Chen et al.
BMC systems biology, 6, 5-5 (2012-01-20)
Drug resistance has now posed more severe and emergent threats to human health and infectious disease treatment. However, wet-lab approaches alone to counter drug resistance have so far still achieved limited success due to less knowledge about the underlying mechanisms
Joan M Korth-Bradley et al.
Clinical therapeutics, 36(6), 982-987 (2014-05-17)
Ethionamide sugar-coated tablets have been reformulated to film-coated tablets to improve dissolution and stability. The study objective was to compare the bioavailability of the film-coated (test) and sugar-coated (reference) formulations of ethionamide. After providing informed consent and undergoing screening procedures
Catherine Vilchèze et al.
Antimicrobial agents and chemotherapy, 55(9), 4422-4423 (2011-06-29)
A search to identify new mechanisms of isoniazid resistance in Mycobacterium bovis led to the isolation of mutants defective in mycothiol biosynthesis due to mutations in genes coding for the glycosyltransferase (mshA) or the cysteine ligase (mshC). These mutants showed
Fluorimetric determination of ethionamide in pharmaceutical preparations and biological fluids.
Walash MI, et al.
J. Chin. Chem. Soc., 51(5A), 1059-1064 (2004)

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