E6530
依托咪酯
>98% (HPLC), GABAA potentiator, powder
别名:
(R)-1-(α-甲苄基)咪唑-5-甲酸乙酯, Amidate, R16659
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关于此项目
经验公式（希尔记法）:
C14H16N2O2
化学文摘社编号:
分子量:
244.29
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
251-385-9
MDL number:
产品名称
依托咪酯, >98% (HPLC), powder
InChI
1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1
InChI key
NPUKDXXFDDZOKR-LLVKDONJSA-N
SMILES string
CCOC(=O)c1cncn1[C@H](C)c2ccccc2
assay
>98% (HPLC)
form
powder
color
white
solubility
DMSO: >10 mg/mL
originator
Johnson & Johnson
storage temp.
2-8°C
Quality Level
Gene Information
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Biochem/physiol Actions
依托咪酯(Etomidate)是一种全身麻醉药；可激活GABAA 信号通路
依托咪酯(Etomidate)是一种全身麻醉药；可激活GABAA信号通路。已有研究，依托咪酯对大鼠脑和脊髓中链脲菌素诱导(STZ-induced)的高血糖具有神经保护作用。依托咪酯治疗对神经组织具有抗糖尿病氧化损伤的神经保护作用。
Features and Benefits
该化合物是神经科学研究推荐产品。点击此处 ，查看更多神经科学精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
该化合物由 Johnson & Johnson 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单， 请单击此处。
General description
依托咪酯(Etomidate)是一种咪唑衍生物，是非巴比妥类催眠药。可用于语言和记忆测试。依托咪酯可通过维持交感神经外流和自主神经反射，维持血流动力学稳定。可抑制肾上腺类固醇生成。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
监管及禁止进口产品
此项目有
Beatrice de la Grandville et al.
European journal of anaesthesiology, 29(11), 511-514 (2012-09-12)
Etomidate is an imidazole-derived hypnotic agent preferentially used for rapid sequence induction of anaesthesia because of its favourable haemodynamic profile. However, 11β-hydroxylase inhibition causes adrenal insufficiency with potentially fatal consequences in specific populations. We review the arguments against the liberal
Sympathetic responses to induction of anesthesia in humans with propofol or etomidate.
Ebert TJ, et al.
Anesthesiology, 76(5), 725-733 (1992)
E Domínguez et al.
Placenta, 34(9), 738-744 (2013-07-10)
Umbilical artery (UA) hemodynamics reflect blood flow and vascular resistance in the placental circulation. We examined non-invasively the hemodynamic effects of propofol, etomidate, and alphaxalone on the placental circulation of a sheep model by means of UA Doppler ultrasonography. Eleven
Laura C McPhee et al.
Critical care medicine, 41(3), 774-783 (2013-01-16)
Retrospective analyses of several trials suggest etomidate may be unsafe for intubation in patients with sepsis. We evaluated the association of etomidate and mortality in a large cohort of septic patients to determine if single-dose etomidate was associated with increased
Inhibition of adrenal steroidogenesis by the anesthetic etomidate
Wagner RL, et al.
The New England Journal of Medicine, 310(22), 1415-1421 (1984)
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