E6530
依托咪酯
>98% (HPLC), GABAA potentiator, powder
别名:
(R)-1-(α-甲苄基)咪唑-5-甲酸乙酯, Amidate, R16659
登录查看公司和协议定价
选择尺寸
关于此项目
经验公式（希尔记法）:
C14H16N2O2
化学文摘社编号:
分子量:
244.29
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
依托咪酯, >98% (HPLC), powder
质量水平
方案
>98% (HPLC)
表单
powder
颜色
white
溶解性
DMSO: >10 mg/mL
创始人
Johnson & Johnson
储存温度
2-8°C
SMILES字符串
CCOC(=O)c1cncn1[C@H](C)c2ccccc2
InChI
1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1
InChI key
NPUKDXXFDDZOKR-LLVKDONJSA-N
正在寻找类似产品? 访问 产品对比指南
一般描述
依托咪酯(Etomidate)是一种咪唑衍生物，是非巴比妥类催眠药。可用于语言和记忆测试。依托咪酯可通过维持交感神经外流和自主神经反射，维持血流动力学稳定。可抑制肾上腺类固醇生成。
生化/生理作用
依托咪酯(Etomidate)是一种全身麻醉药；可激活GABAA 信号通路
依托咪酯(Etomidate)是一种全身麻醉药；可激活GABAA信号通路。已有研究，依托咪酯对大鼠脑和脊髓中链脲菌素诱导(STZ-induced)的高血糖具有神经保护作用。依托咪酯治疗对神经组织具有抗糖尿病氧化损伤的神经保护作用。
特点和优势
该化合物是神经科学研究推荐产品。点击此处 ，查看更多神经科学精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
该化合物由 Johnson & Johnson 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单， 请单击此处。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
监管及禁止进口产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Inhibition of adrenal steroidogenesis by the anesthetic etomidate
Wagner RL, et al.
The New England Journal of Medicine, 310(22), 1415-1421 (1984)
Etomidate speech and memory test (eSAM) A new drug and improved intracarotid procedure
Jones-Gotman M, et al.
Neurology, 65(11), 1723-1729 (2005)
A Möller Petrun et al.
British journal of anaesthesia, 110(3), 388-396 (2012-11-21)
In a double-blind, randomized trial, we compared the haemodynamic effects of a bispectral index (BIS)-guided etomidate and propofol infusion for anaesthesia induction in patients undergoing major abdominal surgery. Forty-six patients were randomly assigned to two groups based on the induction
Laura C McPhee et al.
Critical care medicine, 41(3), 774-783 (2013-01-16)
Retrospective analyses of several trials suggest etomidate may be unsafe for intubation in patients with sepsis. We evaluated the association of etomidate and mortality in a large cohort of septic patients to determine if single-dose etomidate was associated with increased
Beatrice de la Grandville et al.
European journal of anaesthesiology, 29(11), 511-514 (2012-09-12)
Etomidate is an imidazole-derived hypnotic agent preferentially used for rapid sequence induction of anaesthesia because of its favourable haemodynamic profile. However, 11β-hydroxylase inhibition causes adrenal insufficiency with potentially fatal consequences in specific populations. We review the arguments against the liberal
商品
DISCOVER Bioactive Small Molecules for Neuroscience
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持