E7138
乙琥胺
T-type calcium channel antagonist
别名:
2-乙基-2-甲基琥珀酰亚胺
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关于此项目
经验公式（希尔记法）:
C7H11NO2
化学文摘社编号:
分子量:
141.17
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352111
EC Number:
201-048-7
MDL number:
Quality level:
产品名称
乙琥胺,
InChI
1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)
InChI key
HAPOVYFOVVWLRS-UHFFFAOYSA-N
SMILES string
O=C1NC(CC1(C)CC)=O
solubility
ethanol: 100 mg/mL
Quality Level
Gene Information
human ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911)
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相关类别
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Depression is most commonly associated with epilepsy. Recent reports have suggested a putative relationship between seizure development and onset of depressive behavior, whereas others proposed that two clinical entities might represent different neuropathologic aspects of the same neurologic disorder. The
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Epilepsia, 54(4), 635-643 (2013-03-08)
Ethosuximide (ESX) is a drug of choice for the symptomatic treatment of absence seizures. Chronic treatment with ESX has been reported to have disease-modifying antiepileptogenic activity in the WAG/Rij rat model of genetic generalized epilepsy (GGE) with absence seizures. Here
Gilles van Luijtelaar et al.
International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 85(1), 49-54 (2011-09-29)
Recently it was established that early long lasting treatment with the anti-absence drug ethosuximide (ETX) delays the occurrence of absences and reduces depressive-like symptoms in a genetic model for absence epilepsy, rats of the WAG/Rij strain. Here it is investigated
Spike-wave discharges in adult Sprague-Dawley rats and their implications for animal models of temporal lobe epilepsy
Pearce PS, et al.
Epilepsy & Behavior : E&B, 32, 121-131 (2014)
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