E7159
Exo2
≥98% (HPLC)
别名:
2-Methoxy-4-[(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol
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关于此项目
经验公式（希尔记法）:
C18H18N4O2S
化学文摘社编号:
分子量:
354.43
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
Exo2, ≥98% (HPLC)
InChI
1S/C18H18N4O2S/c1-24-14-8-11(6-7-13(14)23)9-21-22-17-16-12-4-2-3-5-15(12)25-18(16)20-10-19-17/h6-10,23H,2-5H2,1H3,(H,19,20,22)/b21-9+
SMILES string
COc1cc(ccc1O)\C=N\Nc2ncnc3sc4CCCCc4c23
InChI key
VFNUTEMVQGLDAG-ZVBGSRNCSA-N
assay
≥98% (HPLC)
form
powder
color
yellow
solubility
DMSO: >20 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Exo2 acts as a chemical probe of intracellular transport.
Exo2 acts as a chemical probe of intracellular transport. Edxo2 has activities similar to Brefeldin A with membrane trafficking to the Golgi appartus, but appears more selective.
Exo2 is a bioactive small molecule that activates Golgi-endoplasmic reticulum (ER) fusion in mammals by distorting the Golgi apparatus. It prevents the release of secretory cargo from the ER. Exo2 do not modify the morphology of the trans-Golgi network (TGN). It also inhibits the anterograde movement of vesicular stomatitis virus G (VSV G) glycoprotein, from ER to Golgi.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Lexiang Ji et al.
The Plant cell, 31(10), 2315-2331 (2019-08-24)
Somatic embryogenesis is an important tissue culture technique that sometimes leads to phenotypic variation via genetic and/or epigenetic changes. To understand the genomic and epigenomic impacts of somatic embryogenesis, we characterized soybean (Glycine max) epigenomes sampled from embryos at 10
Yan Feng et al.
EMBO reports, 5(6), 596-601 (2004-05-22)
Cholera toxin (CT) follows a glycolipid-dependent entry pathway from the plasma membrane through the trans-Golgi network (TGN) to the endoplasmic reticulum (ER) where it is retro-translocated into the cytosol to induce toxicity. Whether access to the Golgi apparatus is necessary
Ayaka Hieno et al.
Plant physiology, 180(3), 1629-1646 (2019-05-09)
Hydrogen peroxide (H2O2) is a common signal molecule initiating transcriptional responses to all the known biotic and abiotic stresses of land plants. However, the degree of involvement of H2O2 in these stress responses has not yet been well studied. Here
Combined targeting of Arf1 and Ras potentiates anticancer activity for prostate cancer therapeutics.
Liwei Lang et al.
Journal of experimental & clinical cancer research : CR, 36(1), 112-112 (2017-08-24)
Although major improvements have been made in surgical management, chemotherapeutic, and radiotherapeutic of prostate cancer, many prostate cancers remain refractory to treatment with standard agents. Therefore, the identification of new molecular targets in cancer progression and development of novel therapeutic
Gertrud Wiedemann et al.
The Plant cell, 30(3), 717-736 (2018-03-09)
RecQ DNA helicases are genome surveillance proteins found in all kingdoms of life. They are characterized best in humans, as mutations in RecQ genes lead to developmental abnormalities and diseases. To better understand RecQ functions in plants we concentrated on
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