E7280
Elafin
recombinant, expressed in Saccharomyces cerevisiae, powder, >90% (by MS, HPLC and SDS-PAGE),
别名:
Elastase-specific inhibitor, skin-derived antileukoprotease
产品名称
Elafin 人, >90% (by MS, HPLC and SDS-PAGE), recombinant, expressed in Saccharomyces cerevisiae
重组
expressed in Saccharomyces cerevisiae
质量水平
方案
>90% (by MS, HPLC and SDS-PAGE)
表单
powder
效能
1.7 x 10-10 M Ki (human leukocyte elastase)
4.2 x 10-10 M Ki (human proteinase 3)
分子量
~6 kDa
UniProt登记号
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
作用机制
enzyme | inhibits
运输
ambient
储存温度
−20°C
基因信息
human ... PI3(5266)
一般描述
Chemical structure: peptide
生化/生理作用
Exhibits co-existent antimicrobial and antiproteolytic activities.1 Inhibits WAP-type four-disulfide core (WFDC) domain containing elastases. Antimicrobial spectrum: Gram-positive and Gram-negative bacteria.
Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage.
Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage. An elastase inhibitor which is an active fragment of elafin, as well as elafin itself, can also be found in bronchial carcinoma secretions.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Viraj J Jasinghe et al.
BioResearch open access, 2(2), 128-137 (2013-04-18)
Trappin-2/elafin is a novel innate immune factor that belongs to the serine protease inhibitor family and has known antibacterial, antifungal, and antiviral properties. In this study, we further investigated the anti-HIV activity of elafin using different cellular models and both
T Dau et al.
Scientific reports, 6, 35413-35413 (2016-10-16)
High abundance proteins like protease inhibitors of plasma display a multitude of interactions in natural environments. Quantitative analysis of such interactions in vivo is essential to study diseases, but have not been forthcoming, as most methods cannot be directly applied
Lingling Shu et al.
Clinical science (London, England : 1979), 134(13), 1679-1696 (2020-07-08)
Type 1 diabetes is an autoimmune disease resulted from self-destruction of insulin-producing pancreatic β cells. However, the pathological pathways that trigger the autoimmune destruction remain poorly understood. Clinical studies have demonstrated close associations of neutrophils and neutrophil elastase (NE) with
Renata Curciarello et al.
Journal of inflammation research, 13, 233-243 (2020-06-18)
Proteases play an essential role in the pathophysiology of inflammatory bowel disease (IBD), contributing to the intestinal mucosal lesions through the degradation of the extracellular matrix and alteration of the barrier function. Ulcerative colitis (UC) is characterized by an extensive
Jiani Wang et al.
Scientific reports, 10(1), 12785-12785 (2020-08-01)
Elafin is an antimicrobial and anti-inflammatory protein. We hypothesize that elafin expression correlates with diabetes. Among non-diabetic and prediabetic groups, men have significantly higher serum elafin levels than women. Men with type 2 diabetes mellitus (T2DM) have significantly lower serum
商品
Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.
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