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Merck
CN

E8031

Sigma-Aldrich

Esmolol 盐酸盐

≥98% (HPLC), β1 adrenoceptor antagonist , solid

别名:

4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzenepropanoic acid methyl ester hydrochloride 盐酸盐

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关于此项目

经验公式（希尔记法）:
C16H26NClO4
化学文摘社编号:
81161-17-3
分子量:
331.83
MDL编号:
MFCD00941432
UNSPSC代码:
12352200
PubChem化学物质编号:
329799075
NACRES:
NA.77

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产品名称

Esmolol 盐酸盐, ≥98% (HPLC), solid

质量水平

100

方案

≥98% (HPLC)

表单

solid

储存条件

desiccated

mp

89.0-90.6 °C

溶解性

H2O: 12 mg/mL

创始人

Baxter

储存温度

2-8°C

SMILES字符串

Cl.COC(=O)CCc1ccc(OCC(O)CNC(C)C)cc1

InChI

1S/C16H25NO4.ClH/c1-12(2)17-10-14(18)11-21-15-7-4-13(5-8-15)6-9-16(19)20-3;/h4-5,7-8,12,14,17-18H,6,9-11H2,1-3H3;1H

InChI key

GEKNCWBANDDJJL-UHFFFAOYSA-N

基因信息

human ... ADRB1(153), ADRB2(154)

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相关类别

应用

Esmolol hydrochloride (ESM) may be used as a standard in spectrophotometric and electrochemical method for the determination of ESM in biological samples and pharmaceutical formulations.

生化/生理作用

Esmolol hydrochloride (ESM) is a class II antiarrhythmic drug. It is used to decrease the force and rate of heart contractions during surgery. Overdose of ESM can lead to side effects such as bradycardia, cardiac arrest, hypoventilation, mood disorder, and coma.
Esmolol hydrochloride is a ultrashort-acting β1 adrenoceptor antagonist (β1 receptor occupancy = 84.7%).

特点和优势

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Baxter. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves

法规信息

监管及禁止进口产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000463574
0000463574
0000445438
0000445438
0000441966

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Electrochemical System for Determination of Esmolol Hydrochloride Using Square Wave Adsorptive Stripping Voltammetry
Alarfaj NA and El-Tohamy MF
International Journal of Electrochemical Science (2016)
Spectrophotometric determination of esmolol hydrochloride using analytical reagents
Narayana A, et al.
Indian Journal of Advances in Chemical Science null
George Dimopoulos et al.
The Journal of surgical research, 198(1), 175-184 (2015-06-16)
Based on previous animal studies showing promising immunomodulatory efficacy esmolol, a selective β1-blocker, it was assumed that administration of esmolol in experimental pyelonephritis by multidrug-resistant Pseudomonas aeruginosa would prolong survival and modulate immune response. Acute pyelonephritis was induced in 80
Yong-Feng Zhu et al.
Journal of laparoendoscopic & advanced surgical techniques. Part A, 25(11), 903-907 (2015-11-18)
To determine the effect of lavage with adrenaline solution on CO2 absorption during retroperitoneal laparoscopic surgery. Sixty patients scheduled to undergo retroperitoneal laparoscopic surgery were divided into an AD group (lavage with normal saline containing adrenaline [1:500,000], n = 30)

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β-Adrenoceptors

β-Adrenoceptors are activated either by norepinephrine or epinephrine. Learn more about the role of β-adrenoceptors in protein expression, cell signaling, and metabolism research.

β-肾上腺素能受体

β-肾上腺素受体可被去甲肾上腺素或肾上腺素激活。详细了解β-肾上腺素受体在蛋白质表达、细胞信号传导和代谢研究中的作用。

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