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E8031

Esmolol 盐酸盐

Name: Esmolol 盐酸盐
Brand: SIGMA

≥98% (HPLC), β1 adrenoceptor antagonist , solid

别名:

4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzenepropanoic acid methyl ester hydrochloride 盐酸盐

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关于此项目

经验公式（希尔记法）:

C₁₆H₂₆NClO₄

化学文摘社编号:

81161-17-3

分子量:

331.83

UNSPSC Code:

12352200

PubChem Substance ID:

329799075

NACRES:

NA.77

MDL number:

MFCD00941432

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

desiccated

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属性

产品名称

Esmolol 盐酸盐, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

mp

89.0-90.6 °C

solubility

H₂O: 12 mg/mL

originator

Baxter

storage temp.

2-8°C

SMILES string

Cl.COC(=O)CCc1ccc(OCC(O)CNC(C)C)cc1

InChI

1S/C16H25NO4.ClH/c1-12(2)17-10-14(18)11-21-15-7-4-13(5-8-15)6-9-16(19)20-3;/h4-5,7-8,12,14,17-18H,6,9-11H2,1-3H3;1H

InChI key

GEKNCWBANDDJJL-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153), ADRB2(154)

说明

Application

Esmolol hydrochloride (ESM) may be used as a standard in spectrophotometric and electrochemical method for the determination of ESM in biological samples and pharmaceutical formulations.

Biochem/physiol Actions

Esmolol hydrochloride (ESM) is a class II antiarrhythmic drug. It is used to decrease the force and rate of heart contractions during surgery. Overdose of ESM can lead to side effects such as bradycardia, cardiac arrest, hypoventilation, mood disorder, and coma.

Esmolol hydrochloride is a ultrashort-acting β₁adrenoceptor antagonist (β₁receptor occupancy = 84.7%).

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Baxter. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000554891

0000463574

0000445438

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商品

β-Adrenoceptors

β-Adrenoceptors are activated either by norepinephrine or epinephrine. Learn more about the role of β-adrenoceptors in protein expression, cell signaling, and metabolism research.

β-肾上腺素能受体

β-肾上腺素受体可被去甲肾上腺素或肾上腺素激活。详细了解β-肾上腺素受体在蛋白质表达、细胞信号传导和代谢研究中的作用。

Esmolol: immunomodulator in pyelonephritis by Pseudomonas aeruginosa.

George Dimopoulos et al.

The Journal of surgical research, 198(1), 175-184 (2015-06-16)

Based on previous animal studies showing promising immunomodulatory efficacy esmolol, a selective β1-blocker, it was assumed that administration of esmolol in experimental pyelonephritis by multidrug-resistant Pseudomonas aeruginosa would prolong survival and modulate immune response. Acute pyelonephritis was induced in 80

Spectrophotometric determination of esmolol hydrochloride using analytical reagents

Narayana A, et al.

Indian Journal of Advances in Chemical Science null

Electrochemical System for Determination of Esmolol Hydrochloride Using Square Wave Adsorptive Stripping Voltammetry

Alarfaj NA and El-Tohamy MF

International Journal of Electrochemical Science (2016)

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全球贸易项目编号

货号	GTIN
E8031-50MG	04061832071985
E8031-10MG	04061833608609