Monoclonal Anti-EEA1 antibody produced in mouse

The gene Early Endosome Antigen 1 (EEA1) encodes for around 1400 amino acid proteins. It is a peripheral membrane protein associated with the cytoplasmic face of early endosomes. EEA1 is a autoantigen associated with subacute cutaneous systemic lupus erythematosus and is a coiled-coil protein localized to early endosomes and cytosol.

Monoclonal Anti-EEA1 antibody produced in mouse is suitable for the following applications:

• Western blotting (at a concentration of 2-4μg/mL using whole extract of rat NRK or human HeLa cells)
• Immunofluorescence Analysis
• Immunocytochemistry

Early Endosome Antigen 1 (EEA1) controls vesicle fusion during endocytosis. In neurons, it is involved in recycling of synaptic vesicles and neurotransmitter receptors. Patients with neurological deficits develop EEA1 autoantibodies. Mutation in EEA1 gene leads to susceptibility to diabetes in the Japanese population. Phosphatidylinositol 3-phosphate (PtdIns(3)P) is essential for the localization and function of EEA1.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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