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E8640

E-64d

Name: E-64d
Brand: SIGMA

powder, ≥98% (TLC)

别名:

(2S,3S)-反式-环氧琥珀酰基-L-亮氨酰氨基-3-甲基丁烷乙酯, EST

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关于此项目

经验公式（希尔记法）:

C₁₇H₃₀N₂O₅

化学文摘社编号:

88321-09-9

分子量:

342.43

UNSPSC Code:

12352202

PubChem Substance ID:

24894681

NACRES:

NA.77

MDL number:

MFCD00132883

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产品名称

E-64d, protease inhibitor

biological source

synthetic (organic)

Quality Level

200

assay

≥98% (TLC)

form

powder

solubility

methanol: water (1:1): 5 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C

InChI

1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1

InChI key

SRVFFFJZQVENJC-IHRRRGAJSA-N

Gene Information

human ... CAPN1(823)

Application

E-64d已作为一种溶酶体抑制剂，被用于人类急性早幼粒细胞白血病NB4细胞和Huh-7细胞中。它也已作为一种蛋白酶抑制剂，被用于游离钙生理酪氨酸溶液中，以用于对分离出的心脏样本的灌注。

Biochem/physiol Actions

E-64d是一种环氧琥珀酰肽，以及半胱氨酸蛋白酶组织蛋白酶B、钙蛋白酶1和2的抑制剂。 E-64d具有对组织蛋白酶B蛋白酶的抑制功能，可作为治疗颅脑外伤（TBI）和阿尔茨海默氏症′（AD）的潜在药物。它可抑制配子体表面抗原，从而减少恶性疟原虫卵囊的产生。

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Inhibition of Plasmodium falciparum oocyst production by membrane-permeant cysteine protease inhibitor E64d

Eksi S, et al.

Antimicrobial Agents and Chemotherapy, 51(3), 1064-1070 (2007)

The cysteine protease inhibitor, E64d, reduces brain amyloid-beta and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, beta-secretase activity

Hook G, et al.

Journal of Alzheimer'S Disease, 26(2), 387-408 (2011)

From EST to novel spider silk gene identification for production of spidroin-based biomaterials.

Weidong Huang et al.

Scientific reports, 7(1), 13354-13354 (2017-10-19)

A cDNA library from a pool of all the seven silk glands from a tropical spider species was constructed. More than 1000 expressed sequence tag (EST) clones were created. Almost 65% of the EST clones were identified and around 50%

Ethambutol neutralizes lysosomes and causes lysosomal zinc accumulation

Yamada D, et al.

Biochemical and Biophysical Research Communications, 471(1), 109-116 (2016)

Evolutionary characteristics of intergenic transcribed regions indicate rare novel genes and widespread noisy transcription in the Poaceae.

John P Lloyd et al.

Scientific reports, 9(1), 12122-12122 (2019-08-23)

Extensive transcriptional activity occurring in intergenic regions of genomes has raised the question whether intergenic transcription represents the activity of novel genes or noisy expression. To address this, we evaluated cross-species and post-duplication sequence and expression conservation of intergenic transcribed

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全球贸易项目编号

货号	GTIN
E8640-1MG	04061833608791
E8640-250UG	04061833608807

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