Merck
CN

E8875

Sigma-Aldrich

β-雌二醇

≥98%

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别名:
17β-雌二醇, 1,3,5-雌三烯-3,17β-二醇, 3,17β-二羟基-1,3,5(10)-雌三烯, 二氢卵泡素
Empirical Formula (Hill Notation):
C18H24O2
CAS号:
分子量:
272.38
Beilstein:
1914275
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

生物来源

synthetic (organic)

质量水平

无菌性

non-sterile

检测方案

≥98%

形式

powder

technique(s)

cell culture | mammalian: suitable

mp

176-180 °C (lit.)

溶解性

ethanol: 50 mg/mL, clear, colorless

运输

ambient

储存温度

room temp

SMILES string

O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C

InChI

1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1

InChI key

VOXZDWNPVJITMN-ZBRFXRBCSA-N

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E2758
β-Estradiol ≥98%

Sigma-Aldrich

E8875

β-雌二醇

β-Estradiol BioReagent, powder, suitable for cell culture

Sigma-Aldrich

E2758

β-雌二醇

form

powder

form

powder

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable, single cell analysis: suitable

solubility

ethanol: 50 mg/mL, clear, colorless

solubility

ethanol: 50 mg/mL, clear, colorless

shipped in

ambient

shipped in

ambient

storage temp.

room temp

storage temp.

room temp

应用

β-雌二醇已用于:
  • 牛卵丘卵母细胞复合体(COC)的体外成熟
  • 作为可用作对照培养基的体外成熟培养基(IVM)中的一种补充剂
  • 雌激素诱导试验

生化/生理作用

绝经前卵巢分泌的主要雌激素。雌激素通过调节基因转录并因此调节蛋白质合成来指导胚胎发生和青春期女性表型的发展。 它还诱导促性腺激素的产生,进而诱导排卵。 暴露于雌二醇会增加乳腺癌的发生率和增殖。

特点和优势

该化合物是受体分类及信号转导手册上乙酰胆碱受体(烟碱)核受体(类固醇)页面上的推荐化合物。想要浏览手册的其他页面, 请单击此处

象形图

Health hazardEnvironment

警示用语:

Danger

危险分类

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

涉药品监管产品

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Three-step in vitro maturation culture of bovine oocytes imitating temporal changes of estradiol-17beta and progesterone concentrations in preovulatory follicular fluid.
Matsuo M, et al.
Archives Animal Breeding, 60(4), 385-390 (2017)
Natriuretic peptide receptor 2 (NPR2) localized in bovine oocyte underlies a unique mechanism for C-type natriuretic peptide (CNP)-induced meiotic arrest.
Xi G, et al.
Theriogenology, 106, 198-209 (2018)
X Xue et al.
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Tamoxifen, an estrogen receptor (ER) antagonist, is the mainstay treatment of breast cancer and the development of resistance represents a major obstacle for a cure. Although long non-coding RNAs such as HOTAIR have been implicated in breast tumorigenesis, their roles
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Hormone therapy targeting estrogen receptor α (ERα) is the most effective treatment for breast cancer. However, this treatment eventually fails as the tumor develops resistance. Although reduced expression of ER-α is a known contributing factor to endocrine resistance, the mechanism
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Calcium ions have been implicated in the establishment and maintenance of pregnancy, but the regulatory mechanisms of calcium ions in the uterine endometrium and conceptus are not well understood in pigs. Recently, we showed that TRPV6, a calcium ion channel

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