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Merck
CN

EHU062581

MISSION® esiRNA

targeting human RPGR

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NACRES:
NA.51
UNSPSC Code:
41105324

主要文件

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产品名称

MISSION® esiRNA, targeting human RPGR

description

Powered by Eupheria Biotech

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

AGCAGCTGTCTGCTGGATCTAATACTTCAGCTGCCCTAACTGAGGATGGAAGACTTTTTATGTGGGGTGACAATTCCGAAGGGCAAATTGGTTTAAAAAATGTAAGTAATGTCTGTGTCCCTCAGCAAGTGACCATTGGGAAACCTGTCTCCTGGATCTCTTGTGGATATTACCATTCAGCTTTTGTAACAACAGATGGTGAGCTATATGTGTTTGGAGAACCTGAGAATGGGAAGTTAGGTCTTCCCAATCAGCTCCTGGGCAATCACAGAACACCCCAGCTGGTGTCTGAAATTCCGGAGAAGGTGATCCAAGTAGCCTGTGGTGGAGAGCATACTGTGGTTCTCACGGAGAATGCTGTGTATACCTTTGGGCTGGGACAATTTGGTCAGCTGGGTCTTGGCACTTTTCTTTTTG

Ensembl | human accession no.

ENSG00000156313

NCBI accession no.

NM_000328

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Gene Information

human ... RPGR(6103), RPGR(6103)

General description

MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Carlos A Murga-Zamalloa et al.
Human molecular genetics, 19(18), 3591-3598 (2010-07-16)
Defects in biogenesis or function(s) of primary cilia are associated with numerous inherited disorders (called ciliopathies) that may include retinal degeneration phenotype. The cilia-expressed gene RPGR (retinitis pigmentosa GTPase regulator) is mutated in patients with X-linked retinitis pigmentosa (XLRP) and
Roly Megaw et al.
Nature communications, 8(1), 271-271 (2017-08-18)
Mutations in the Retinitis Pigmentosa GTPase Regulator (RPGR) cause X-linked RP (XLRP), an untreatable, inherited retinal dystrophy that leads to premature blindness. RPGR localises to the photoreceptor connecting cilium where its function remains unknown. Here we show, using murine and

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