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Merck
CN

EMU036241

MISSION® esiRNA

targeting mouse Ap1m2

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NACRES:
NA.51
UNSPSC Code:
41105324

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产品名称

MISSION® esiRNA, targeting mouse Ap1m2

description

Powered by Eupheria Biotech

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

ATCACACAACAGGGCAACAAGCTGGAGACTGGCAAATCTCGTGTACCACCTACAGTCACCAATGCGGTGTCGTGGCGCTCTGAGGGCATTAAGTACAAAAAGAATGAGGTCTTCATTGATGTCATTGAGTCTGTCAACCTTCTGGTCAATGCTAATGGGAGTGTCTTGCTCAGCGAGATTGTGGGCACCATCAAGCTGAAGGTGTTTCTGTCTGGGATGCCAGAGCTGCGGCTGGGCCTCAATGACCGAGTGCTCTTTGAGCTTACTGGCCGCAGCAAGAACAAGTCTGTGGAACTGGAAGATGTGAAATTCCACCAATGTGTGAGGCTTTCACGCTTTGACAACGACCGAACCATCTCCTTCATACCCCCAGATGGGGACTTTGAACTCATGTCCTACCGGCTTAGCACCCAGGTCAAACCCCTGATCTGGATCGAGTCAGTCATTGAGAAATTCTCGCACAGCCGAGTGGAGATCATGGTGAAGGCCAAG

Ensembl | mouse accession no.

ENSMUSG00000003309

NCBI accession no.

NM_009678

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Gene Information

mouse ... AP1M2(11768), Ap1m2(11768)

Biochem/physiol Actions

Ap1m2 (AP-1 complex subunit μ-2) is a μ1B subunit of AP-1B (adaptor protein). In polarised epithelial cells, AP-1B is responsible for basolateral sorting of membrane proteins. Absence of the Ap1m2 gene in mice results in T-helper (Th)17-dominant colitis and intestinal epithelial cell hyperplasia. Ap1m2 is associated with expression of antimicrobial proteins and the luminal transport of secretory IgA (immunoglobulin A).

General description

MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
KSU
KRU

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AP-1B-mediated protein sorting regulates polarity and proliferation of intestinal epithelial cells in mice.
Hase K
Gastroenterology, 145, 625-625 (2013)
The epithelia-specific membrane trafficking factor AP-1B controls gut immune homeostasis in mice.
Takahashi D
Gastroenterology, 141, 621-621 (2011)

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