description
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Quality Level
product line
MISSION®
form
lyophilized powder
esiRNA cDNA target sequence
ATCACACAACAGGGCAACAAGCTGGAGACTGGCAAATCTCGTGTACCACCTACAGTCACCAATGCGGTGTCGTGGCGCTCTGAGGGCATTAAGTACAAAAAGAATGAGGTCTTCATTGATGTCATTGAGTCTGTCAACCTTCTGGTCAATGCTAATGGGAGTGTCTTGCTCAGCGAGATTGTGGGCACCATCAAGCTGAAGGTGTTTCTGTCTGGGATGCCAGAGCTGCGGCTGGGCCTCAATGACCGAGTGCTCTTTGAGCTTACTGGCCGCAGCAAGAACAAGTCTGTGGAACTGGAAGATGTGAAATTCCACCAATGTGTGAGGCTTTCACGCTTTGACAACGACCGAACCATCTCCTTCATACCCCCAGATGGGGACTTTGAACTCATGTCCTACCGGCTTAGCACCCAGGTCAAACCCCTGATCTGGATCGAGTCAGTCATTGAGAAATTCTCGCACAGCCGAGTGGAGATCATGGTGAAGGCCAAG
Ensembl | mouse accession no.
NCBI accession no.
shipped in
ambient
storage temp.
−20°C
Gene Information
mouse ... AP1M2(11768), Ap1m2(11768)
General description
MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.
For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.
For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.
Biochem/physiol Actions
Ap1m2 (AP-1 complex subunit μ-2) is a μ1B subunit of AP-1B (adaptor protein). In polarised epithelial cells, AP-1B is responsible for basolateral sorting of membrane proteins. Absence of the Ap1m2 gene in mice results in T-helper (Th)17-dominant colitis and intestinal epithelial cell hyperplasia. Ap1m2 is associated with expression of antimicrobial proteins and the luminal transport of secretory IgA (immunoglobulin A).
Legal Information
MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
AP-1B-mediated protein sorting regulates polarity and proliferation of intestinal epithelial cells in mice.
Hase K
Gastroenterology, 145, 625-625 (2013)
The epithelia-specific membrane trafficking factor AP-1B controls gut immune homeostasis in mice.
Takahashi D
Gastroenterology, 141, 621-621 (2011)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| EMU036241-20UG | 04061828496402 |
| EMU036241-50UG | 04061828271146 |