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Merck
CN

EMU043381

MISSION® esiRNA

targeting mouse Ska1

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NACRES:
NA.51
UNSPSC Code:
41105324

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产品名称

MISSION® esiRNA, targeting mouse Ska1

description

Powered by Eupheria Biotech

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

ACCCTGCCTTGAAGACCACCTTAAGTAAAATAGGAGATGAGATCATTGCAGTAAATGAGCTTCTAAATAAATTTGAATTGGAAATTCAGTATCAAGAACAAACTAACAGTTCACTCAAGGAGCTCTGTGAATCTCTTAGAGAAGAGTGTGAAGATGTGGAACATCTCAAAGAACACGTCCCTCCCCATCTGCCTCAAGTGACGGCGACCCAGAGCTTAGTTCACAAGCCCGAGCCGGATCCTAAAGAGTCAGACAAAGCTGAGGAGCCTGGACTGCCGAAGAAGCCCCCCAGAGAGCAGAGAGTTATCAAGGAAATGCAATTTATAACTATGGATGAATTCAGTGACGTTCCTGCGTACATGAAATCCCGTTTAACATATTGTCAAATTAATGATATTATTAAGGAAATTAACAAGGCAGTAGTTAGCAAATATAAGATTATGCATCAACCAAAAGCATCTATGAGCTCTGTGAAGAGAAATCTCTACCAGAGATTTATTAATGAAGAAACGAAGGACACGAAAGGTCATCACTTCATCGTGGAAGCTG

Ensembl | mouse accession no.

ENSMUSG00000036223

NCBI accession no.

NM_025581

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Gene Information

mouse ... SKA1(66468), 2810433K01Rik(66468)

General description

MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Lihua Shen et al.
Oncology reports, 35(5), 2561-2568 (2016-03-18)
Currently, chemotherapy with platinum-based drugs including cisplatin is the most effective therapy for the treatment of non-small cell lung carcinoma (NSCLC). However, the efficacy of chemotherapy is limited due to commonly developed drug resistance. Spindle and kinetochore-associated complex subunit 1
Sushama Sivakumar et al.
Molecular biology of the cell, 25(5), 594-605 (2014-01-10)
The spindle and kinetochore-associated (Ska) protein complex is a heterotrimeric complex required for timely anaphase onset. The major phenotypes seen after small interfering RNA-mediated depletion of Ska are transient alignment defects followed by metaphase arrest that ultimately results in cohesion

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