description
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product line
MISSION®
form
lyophilized powder
esiRNA cDNA target sequence
TAATGACCCTGGGTGGAAAAATTTGACAGTTATATTATCTGATGCTAGTGCACCTGGTGAAGGAGAACACAAAATCATGGATTACATTAGAAGACAAAGAGCCCAGCCTAACCAGGACCCAAATACTCATCATTGTTTGTGTGGAGCTGATGCTGATCTAATTATGCTTGGTCTTGCTACACATGAACCTAACTTCACCATAATCAGAGAAGAATTCAAACCAAATAAACCTAAACCATGTGCTCTTTGTAATCAGTTTGGACACGAGGTCAAGGATTGTGAAGGTTTGCCAAGAGAAAAGAAGGGAAAGCATGATGAACTTGCAGATAGTCTTCCTTGTGCAGAAGGGGAGTTTATCTTCCTTCGGCTGAATGTCCTTCGAGAGTATCTGGAAAGAGAACTCACCATGGCCAGCTTACCATTCCCATTTGATGTGGAGAGGAGCAATGATGACTGGGAGTTCATGTGCTTCTTTGTGGGGAATGATTTCCTTCCTCACTTGCCATC
Ensembl | mouse accession no.
NCBI accession no.
shipped in
ambient
storage temp.
−20°C
Quality Level
Gene Information
mouse ... XRN2(24128), Xrn2(24128)
General description
MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.
For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.
For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.
Legal Information
MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Shin-Ichiro Hori et al.
Biochemical and biophysical research communications, 464(2), 506-511 (2015-07-15)
Antisense oligonucleotides (ASOs) can suppress the expression of a target gene by cleaving pre-mRNA and/or mature mRNA via RNase H1. Following the initial endonucleolytic cleavage by RNase H1, the target RNAs are degraded by a mechanism that is poorly understood.
Oussama Meziane et al.
Scientific reports, 5, 16688-16688 (2015-11-21)
The decapping scavenger enzyme DcpS is known for its role in hydrolyzing the cap structure following mRNA degradation. Recently, we discovered a new function in miRNA degradation activation for the ortholog of DcpS in C. elegans. Here we show that
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