EPS002
MS-275
A HDAC1 and HDAC3 inhibitor
别名:
MS-275 (Entinostat, SNDX-275), 3-吡啶基甲基[[4-[[(2-氨基苯基)氨基]羰基]苯基]甲基]氨基甲酸酯, N-(2-氨基苯基)-4-[N-(吡啶-3-甲氧基羰基)氨甲基]苯甲酰胺
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关于此项目
经验公式（希尔记法）:
C21H20N4O3
化学文摘社编号:
分子量:
376.41
NACRES:
NA.41
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
MS-275, A HDAC1 and HDAC3 inhibitor
InChI
1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)
SMILES string
Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2
InChI key
INVTYAOGFAGBOE-UHFFFAOYSA-N
assay
≥99%
solubility
DMSO: 38 mg/mL
storage temp.
−20°C
Gene Information
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Application
MS-275已被用作组蛋白脱乙酰酶-1抑制剂。
Biochem/physiol Actions
HDAC抑制剂，抗增殖。
General description
优先于HDAC3（IC50=8 μM）抑制HDAC1（IC50 = 300nM）。 对HDAC8（IC50>100 μM）无抑制活性。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Repr. 1A
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Heather MacTavish et al.
PloS one, 5(12), e14462-e14462 (2011-02-02)
Histone deacetylase inhibitors (HDI) dampen cellular innate immune response by decreasing interferon production and have been shown to increase the growth of vesicular stomatitis virus and HSV. As attenuated tumour-selective oncolytic vaccinia viruses (VV) are already undergoing clinical evaluation, the
Guido Dentesano et al.
Journal of neuroinflammation, 9, 165-165 (2012-07-11)
In physiological conditions, it is postulated that neurons control microglial reactivity through a series of inhibitory mechanisms, involving either cell contact-dependent, soluble-factor-dependent or neurotransmitter-associated pathways. In the current study, we focus on CD200R1, a microglial receptor involved in one of
HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis
TingDong Y et al.
Nature Communications, 100 (2018)
Marta Bombardo et al.
Scientific reports, 8(1), 9391-9391 (2018-06-22)
Adult pancreatic acinar cells have the ability to re-enter the cell cycle and proliferate upon injury or tissue loss. Despite this mitotic ability, the extent of acinar proliferation is often limited and unable to completely regenerate the injured tissue or
Na Liu et al.
PloS one, 8(1), e54001-e54001 (2013-01-24)
Histone deacetylase (HDAC) inhibitors are promising anti-fibrosis drugs; however, nonselective inhibition of class I and class II HDACs does not allow a detailed elucidation of the individual HDAC functions in renal fibrosis. In this study, we investigated the effect of
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