F0287
来自人血浆的纤连蛋白蛋白水解片段
lyophilized powder, 70 kDa
别名:
纤连蛋白 溶液 来源于人类成纤维细胞
登录 查看组织和合同定价。
选择尺寸
关于此项目
Form:
lyophilized powder
Assay:
>90% (SDS-PAGE)
Biological source:
human plasma
Mol wt:
70 kDa
产品名称
来自人血浆的纤连蛋白蛋白水解片段, lyophilized powder, 70 kDa
biological source
human plasma
assay
>90% (SDS-PAGE)
form
lyophilized powder
mol wt
70 kDa
packaging
pkg of 0.5 mg
technique(s)
cell culture | mammalian: suitable
impurities
HIV and HBsAg, source material tested negative
Small proteolytic fragments, may contain traces
solubility
water: soluble ≥0.500 mg/mL, clear to slightly hazy, colorless
UniProt accession no.
shipped in
ambient
storage temp.
−20°C
Quality Level
Gene Information
human ... FN1(2335)
正在寻找类似产品? 访问 产品对比指南
Application
Fibronectin Proteolytic Fragment from human plasma has been used in pre adsorbed antibody blocking assay and EC-pericyte tube coassembly.
Biochem/physiol Actions
Fibronectin participates in cell adhesion, growth, migration, wound healing, blood coagulation and metastasis. Mutations in FN1 results in glomerulopathy. It plays an important role in cell attachment and spreading, control of cell cytoskeleton, morphology and differentiation. FN1 is also involved in extracellular matrix formation, hemostasis and thrombosis. Proteolytic fragments of fibronectin plays a vital role in mononuclear phagocyte function.
Disclaimer
The product should be stored at -20°C.
General description
Fibronectin 1 is a glycoprotein of the extracellular matrix that is coded by FN1 gene. It is expressed in the plasma and at the cell surface. FN1 is mapped to human chromosome 2q35. Proteolytic fragments of fibronectin has a cell binding domain.
Preparation Note
This product is lyophilized from phosphate buffered saline with sucrose as a cryoprotectant. The source material has tested negative for antibody to HIV, HCN, and HBsAg. It is soluble in water at 0.5 mg/mL and yields a clear to slightly hazy solution.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
高风险级别生物产品--人源产品
此项目有
Fibronectin in Health and Disease (2018)
C Penn et al.
Microbial pathogenesis, 17(6), 387-393 (1994-12-01)
Candida albicans yeast cells bind soluble human plasma fibronectin (Fn) through a glycoprotein receptor (adhesin) located on the cell surface. This work demonstrates that a 120 kDa proteolytic fragment of Fn encompassing the cell binding domain binds more avidly to
Mutations F352A and Y528A in human HSP90I? reduce fibronectin association and fibrillogenesis in cell-derived matrices.
Chakraborty, et al.
Cell Stress & Chaperones (2023)
Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation.
Stratman A N, et al.
Blood, 114(24), 5091-5101 (2009)
Ail protein binds ninth type III fibronectin repeat (9FNIII) within central 120 kDa region of fibronectin to facilitate cell binding by Yersinia pestis.
Tsang T M, et al.
The Journal of Biological Chemistry, 287(20), 16759-16767 (2012)
实验方案
Dilute fibronectin for cell attachment, varying per cell type. Coating protocol, products, and FAQs provided.
相关内容
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持