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F0778

Felbamate

Name: Felbamate
Brand: SIGMA

NMDA glutamate receptor antagonist

别名:

2-Phenyl-1,3-propanediol dicarbamate

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关于此项目

经验公式（希尔记法）:

C₁₁H₁₄N₂O₄

化学文摘社编号:

25451-15-4

分子量:

238.24

NACRES:

NA.77

PubChem Substance ID:

24277968

UNSPSC Code:

12352200

EC Number:

247-001-4

MDL number:

MFCD00865296

Quality level:

200

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产品名称

Felbamate,

Quality Level

200

solubility

alcohol: soluble

SMILES string

NC(=O)OCC(COC(N)=O)c1ccccc1

InChI

1S/C11H14N2O4/c12-10(14)16-6-9(7-17-11(13)15)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H2,12,14)(H2,13,15)

InChI key

WKGXYQFOCVYPAC-UHFFFAOYSA-N

Gene Information

human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444)

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Biochem/physiol Actions

Anticonvulsant agent that is an allosteric antagonist at the NR2B subunit of the NMDA glutamate receptor; also has γ-aminobutyric acid (GABA_A) receptor agonist properties.

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation.

P Glue et al.

Clinical pharmacokinetics, 33(3), 214-224 (1997-10-07)

This article provides an analysis of the degree of agreement between in vivo interaction studies performed in patients with epilepsy and healthy individuals, and in vitro studies which identified the cytochromes P450 (CYP) inhibited by felbamate and those involved in

Felbamate.

I E Leppik

Epilepsia, 36 Suppl 2, S66-S72 (1995-01-01)

After the first year of clinical experience, felbamate (FBM) appears to be a valuable antiepileptic drug (AED) for the treatment of intractable epilepsy. However, many patients experience side effects that may discourage continued usage. These may be decreased by using

Simultaneous HPLC-UV analysis of rufinamide, zonisamide, lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in deproteinized plasma of patients with epilepsy.

Manuela Contin et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(3-4), 461-465 (2009-12-17)

We present an implementation of a method we previously reported allowing the newer antiepileptic drugs (AEDs) rufinamide (RFN) and zonisamide (ZNS) to be simultaneously determined with lamotrigine (LTG), oxcarbazepine's (OXC) main active metabolite monohydroxycarbamazepine (MHD) and felbamate (FBM) in plasma

Efficacy of felbamate in the treatment of intractable pediatric epilepsy.

Mary L Zupanc et al.

Pediatric neurology, 42(6), 396-403 (2010-05-18)

The antiepileptic drug felbamate has demonstrated efficacy against a variety of seizure types in the pediatric population, particularly seizures associated with Lennox-Gastaut syndrome. Postmarketing experience, however, revealed serious idiosyncratic adverse effects not observed during clinical trials, including aplastic anemia and

Is there any future for felbamate treatment?

Kinga K Borowicz et al.

Polish journal of pharmacology, 56(3), 289-294 (2004-06-25)

Felbamate (2-phenyl-1,3-propanediol dicarbamate), a representative of novel antiepileptic drugs (AESs), proved to have broad-spectrum anticonvulsive activity. Particularly beneficial efficacy was found against partial seizures and Lennox-Gastaut syndrome. Therefore, felbamate started to be indicated not only as an adjunctive antiepileptic drug

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全球贸易项目编号

货号	GTIN
F0778-50MG	04061832556512
F0778-10MG	04061833611401

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