biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~49 kDa
species reactivity
human
technique(s)
western blot: 1:500-1:2,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... FNTB(2342)
Immunogen
synthetic peptide corresponding to amino acids 276-290 of human FNTB
Application
Anti-FNTB (276-290) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:2,000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
Biochem/physiol Actions
Protein farnesyltransferase subunit β is an enzyme encoded by the FNTB gene in humans and is located on human chromosome bands 14q23-q24. It helps in catalyzing the biologically relevant lipidation of cellular proteins. FTase may play an important role in the genesis and development of primary liver cancer (PLC). It may act as a reliable marker for the metastatic activity gained by liver tumor cells. FTase may be used clinically in predicting metastatic recurrence of PLC. Farnesyl protein transferase (FPTase) inhibitors (FTIs) were also developed as potential anticancer agents targeting the ras oncogene and also for parasitic infections.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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