F100
氟司必林
别名:
8-[4,4-双(p-氟苯)丁基]-1-苯基-1,3,8-三氮杂螺[4.5]癸-4-酮, R 6218
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关于此项目
经验公式（希尔记法）:
C29H31F2N3O
化学文摘社编号:
分子量:
475.57
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
217-418-6
MDL number:
InChI key
QOYHHIBFXOOADH-UHFFFAOYSA-N
InChI
1S/C29H31F2N3O/c30-24-12-8-22(9-13-24)27(23-10-14-25(31)15-11-23)7-4-18-33-19-16-29(17-20-33)28(35)32-21-34(29)26-5-2-1-3-6-26/h1-3,5-6,8-15,27H,4,7,16-21H2,(H,32,35)
SMILES string
Fc1ccc(cc1)C(CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4)c5ccc(F)cc5
assay
≥98% (HPLC)
form
solid
color
white
solubility
DMSO: ≥20 mg/mL, H2O: insoluble, ethanol: soluble
originator
Johnson & Johnson
storage temp.
room temp
Quality Level
Gene Information
human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)
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Application
氟司必林已用于研究其作为神经安定药物对人ether-a-go-go相关基因(HERG)的影响。
氟司必林已用于研究其对恶性神经胶质瘤的细胞毒性作用。
Biochem/physiol Actions
氟司必林(Fluspirilene)是一种多巴胺受体拮抗剂。也可充当钙通道阻断剂。氟司必林是一种抗精神病药物，具有精神安定作用。对胶质母细胞瘤和精神分裂症有治疗作用。
氟司必林可抑制周期蛋白依赖性激酶2(CDK2)的活性。可作为抗癌药有效治疗人肝细胞癌。
Features and Benefits
该化合物由 Johnson & Johnson 开发。浏览其他由制药公司开发的化合物以及批准药物/候选药物清单， 请单击此处。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Christine Zalejski et al.
Plant physiology, 141(4), 1555-1562 (2006-06-13)
Diacylglycerol pyrophosphate (DGPP) was recently shown to be a possible intermediate in abscisic acid (ABA) signaling. In this study, reverse transcription-PCR of ABA up-regulated genes was used to evaluate the ability of DGPP to trigger gene expression in Arabidopsis (Arabidopsis
Su-Jane Wang
Synapse (New York, N.Y.), 44(1), 36-41 (2002-02-14)
Fluspirilene, a neuroleptic drug which is used clinically to treat schizophrenic patients, is a dopamine D2 receptor antagonist. Besides its well-known actions on the dopamine receptors, fluspirilene also displays calcium channel-blocking activity. The aim of this study was to investigate
Depot fluspirilene for schizophrenia
Abhijnhan A, et al.
Cochrane database of systematic reviews (Online), 8(1), 111728-111728 (2007)
C J Grantham et al.
British journal of pharmacology, 111(2), 483-488 (1994-02-01)
1. High voltage-activated calcium currents were recorded in nerve growth factor (NGF)-differentiated PC12 cells with the whole-cell patch clamp technique. After exposure to NGF for 3-10 days the PC12 cells developed neurone-like processes and calcium currents which were pharmacologically separable
Fluspirilene block of N-type calcium current in NGF-differentiated PC 12 cells
Grantham, CJ and Main, MJ and Cannell, MB
British Journal of Pharmacology, 111(2), 483-488 (1994)
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