F112
(+)-芬氟拉明 盐酸盐
serotonin uptake inhibitor, powder
别名:
(+)-N-Ethyl-α-methyl-m-[trifluoromethyl]phenethylamine hydrochloride, Dexfenfluramine hydrochloride
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关于此项目
经验公式（希尔记法）:
C12H16F3N · HCl
化学文摘社编号:
分子量:
267.72
EC 号:
MDL编号:
UNSPSC代码:
12352116
PubChem化学物质编号:
NACRES:
NA.77
产品名称
(+)-芬氟拉明 盐酸盐,
表单
powder
质量水平
药品控制
USDEA Schedule IV
颜色
white to off-white
溶解性
H2O: soluble 10 mg/mL
应用
forensics and toxicology
储存温度
room temp
SMILES字符串
Cl[H].CCN[C@@H](C)Cc1cccc(c1)C(F)(F)F
InChI
1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H/t9-;/m0./s1
InChI key
ZXKXJHAOUFHNAS-FVGYRXGTSA-N
生化/生理作用
(+)-Fenfluramine is a serotonin uptake inhibitor; anoxexic.
(+)-Fenfluramine is a serotonin uptake inhibitor; anoxexic. (+)-Fenfluramine is neurotoxic on prolonged administration or at high dosage. (+)-Fenfluramine releases serotonin from axon terminals by a nonexocytotic mechanism.
其他说明
Active isomer
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Effects of d- and 1-fenfluramine on striatal homovanillic acid concentrations in rats after pharmacological manipulation of brain serotonin.
V Crunelli et al.
Pharmacological research communications, 12(3), 215-223 (1980-03-01)
Dan Jones
Nature reviews. Drug discovery, 7(12), 961-962 (2008-12-02)
A wave of terminations of development programmes for cannabinoid receptor 1 blockers for obesity indicates the demise of a drug class that was once anticipated to yield blockbusters. Nevertheless, lessons learned might help salvage something for future such approaches.
Delphine Natali et al.
Chest, 140(4), 1066-1068 (2011-10-06)
We report a case of pulmonary arterial hypertension (PAH) occurring in a patient with Cowden syndrome with a mutation in the phosphatase and tensin (PTEN) tumor suppressor gene, in the context of exposure to the appetite suppressant dexfenfluramine. Anorexigen exposure
Nicolas Desbuards et al.
European journal of pharmacology, 602(2-3), 355-363 (2008-12-04)
The anorectic drug, dexfenfluramine has been associated with an increase in the relative risk of developing pulmonary hypertension. 5-hydroxytryptamine (5-HT) is a mitogen for smooth muscle cell, an effect that relies on 5-HT transporter expression and which has been proposed
Margaret R Maclean et al.
Advances in experimental medicine and biology, 661, 309-322 (2010-03-06)
The serotonin hypothesis of pulmonary arterial hypertension (PAH) arose after an outbreak of PAH in patients taking the anorexigenic drugs aminorex and dexfenfluramine. Both of these drugs are serotonin transporter (SERT) substrates and indirect serotinergic agonists. There is now a
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