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Merck
CN

F112

(+)-芬氟拉明 盐酸盐

serotonin uptake inhibitor, powder

别名:

(+)-N-Ethyl-α-methyl-m-[trifluoromethyl]phenethylamine hydrochloride, Dexfenfluramine hydrochloride

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关于此项目

经验公式(希尔记法):
C12H16F3N · HCl
化学文摘社编号:
分子量:
267.72
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
221-806-0
MDL number:
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产品名称

(+)-芬氟拉明 盐酸盐,

InChI key

ZXKXJHAOUFHNAS-FVGYRXGTSA-N

InChI

1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H/t9-;/m0./s1

SMILES string

Cl[H].CCN[C@@H](C)Cc1cccc(c1)C(F)(F)F

form

powder

drug control

USDEA Schedule IV

color

white to off-white

solubility

H2O: soluble 10 mg/mL

application(s)

forensics and toxicology

storage temp.

room temp

Quality Level

Biochem/physiol Actions

(+)-Fenfluramine is a serotonin uptake inhibitor; anoxexic.
(+)-Fenfluramine is a serotonin uptake inhibitor; anoxexic. (+)-Fenfluramine is neurotoxic on prolonged administration or at high dosage. (+)-Fenfluramine releases serotonin from axon terminals by a nonexocytotic mechanism.

Other Notes

Active isomer

pictograms

Skull and crossbones

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Korneel Rabaey et al.
Current opinion in biotechnology, 22(3), 371-377 (2011-03-01)
The production of biofuels and biochemicals is highly electron intensive. To divert fermentative and respiratory pathways to the product of interest, additional electrons (i.e. reducing power) are often needed. Meanwhile, the past decade has seen the breakthrough of sustainable electricity
Dan Jones
Nature reviews. Drug discovery, 7(12), 961-962 (2008-12-02)
A wave of terminations of development programmes for cannabinoid receptor 1 blockers for obesity indicates the demise of a drug class that was once anticipated to yield blockbusters. Nevertheless, lessons learned might help salvage something for future such approaches.
Delphine Natali et al.
Chest, 140(4), 1066-1068 (2011-10-06)
We report a case of pulmonary arterial hypertension (PAH) occurring in a patient with Cowden syndrome with a mutation in the phosphatase and tensin (PTEN) tumor suppressor gene, in the context of exposure to the appetite suppressant dexfenfluramine. Anorexigen exposure
Margaret R Maclean et al.
Advances in experimental medicine and biology, 661, 309-322 (2010-03-06)
The serotonin hypothesis of pulmonary arterial hypertension (PAH) arose after an outbreak of PAH in patients taking the anorexigenic drugs aminorex and dexfenfluramine. Both of these drugs are serotonin transporter (SERT) substrates and indirect serotinergic agonists. There is now a
Effects of d- and 1-fenfluramine on striatal homovanillic acid concentrations in rats after pharmacological manipulation of brain serotonin.
V Crunelli et al.
Pharmacological research communications, 12(3), 215-223 (1980-03-01)

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