F114
顺式-(Z)-氟噻唑 二盐酸盐
≥98% (HPLC), solid
别名:
(Z)-4-[3-[2-(三氟甲基)-9H-噻吨基-9-亚丙基]丙基] -1-哌嗪乙醇 二盐酸盐, 氟哌噻吨 二盐酸盐
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关于此项目
经验公式（希尔记法）:
C23H25F3N2OS · 2HCl
化学文摘社编号:
分子量:
507.44
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
InChI
1S/C23H25F3N2OS.2ClH/c24-23(25,26)17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)30-22)5-3-9-27-10-12-28(13-11-27)14-15-29;;/h1-2,4-8,16,29H,3,9-15H2;2*1H/b18-5-;;
SMILES string
Cl[H].Cl[H].OCCN1CCN(CC\C=C2\c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1
InChI key
IOVDQEIIMOZNNA-MHKBYHAFSA-N
assay
≥98% (HPLC)
form
solid
color
white to off-white
solubility
H2O: soluble
originator
Lundbeck
Quality Level
Gene Information
human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)
General description
顺式-(Z)-盐酸氟哌噻吨(FLU)是一种噻吨蒽药物。DRD1（多巴胺受体 D1）编码位于人类 5q35.2 染色体上的 D1R。多巴胺 D1 在肺泡 I 型细胞中表达。
Application
顺式-(Z)-氟哌噻吩盐酸盐已用于药物输注。它已被用来确定社会游戏行为与胞外 LS-DA 和 LS-NE 释放模式的因果关系。
Biochem/physiol Actions
抗精神病药；抗精神病药；多巴胺受体拮抗剂。顺式-(Z)-盐酸氟哌噻吨 (FLU)用于治疗精神分裂症和抗焦虑和抑郁症。多巴胺 D1 在肺液稳态中起主要作用。它通过产生腺苷酸环化酶/cAMP 来控制气道平滑肌张力，这将有助于哮喘患者气道舒张。肺中的多巴胺作为神经递质和去甲肾上腺素的前体。
Legal Information
经 H. Lundbeck A/S 许可出售。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
The dopamine D 1 receptor is expressed and induces CREB phosphorylation and MUC5AC expression in human airway epithelium
Matsuyama N, et al.
Respiratory Research, 19(1), 53-53 (2018)
Transcriptomic context of DRD1 is associated with prefrontal activity and behavior during working memory
Fazio L, et al.
Proceedings of the National Academy of Sciences of the USA, 115(21), 5582-5587 (2018)
Involvement of dopamine, but not norepinephrine, in the sex-specific regulation of juvenile socially rewarding behavior by vasopressin
Bredewold R, et al.
Neuropsychopharmacology (2018)
Pharmacological properties of new antipsychotic agents: use of animal models.
A J Puech et al.
Neuropharmacology, 20(12B), 1279-1284 (1981-12-01)
Effect of cis-(Z)-flupentixol on DPPC membranes in the presence and absence of cholesterol
Yonar D and Sunnetcioglu M M
Chemistry and Physics of Lipids, 198, 61-71 (2016)
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