F1147

Fumonisin B₁

Name: Fumonisin B&#8321;
Brand: SIGMA

From Fusarium sp. (Fusarium moniliforme), ≥98% (HPLC), ceramide synthase (sphingosine N-acetyltransferase) inhibitor, powder

别名:

Macrofusine

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关于此项目

经验公式（希尔记法）:

C₃₄H₅₉NO₁₅

化学文摘社编号:

116355-83-0

分子量:

721.83

UNSPSC Code:

12352200

PubChem Substance ID:

24894752

NACRES:

NA.32

MDL number:

MFCD27977580

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产品名称

Fumonisin B₁ 来源于串珠镰刀菌, ≥98% (HPLC)

form

powder

SMILES string

CCCC[C@@H](C)[C@@H](OC(=O)C[C@@H](CC(O)=O)C(O)=O)[C@H](C[C@@H](C)C[C@H](O)CCCC[C@@H](O)C[C@H](O)[C@H](C)N)OC(=O)C[C@@H](CC(O)=O)C(O)=O

InChI

1S/C34H59NO15/c1-5-6-9-20(3)32(50-31(44)17-23(34(47)48)15-29(41)42)27(49-30(43)16-22(33(45)46)14-28(39)40)13-19(2)12-24(36)10-7-8-11-25(37)18-26(38)21(4)35/h19-27,32,36-38H,5-18,35H2,1-4H3,(H,39,40)(H,41,42)(H,45,46)(H,47,48)/t19-,20+,21-,22+,23+,24+,25+,26-,27-,32+/m0/s1

InChI key

UVBUBMSSQKOIBE-DSLOAKGESA-N

biological source

Fusarium sp. (Fusarium moniliforme)

assay

≥98% (HPLC)

solubility

methanol: 9.80-10.20 mg/mL, clear, colorless to light yellow

storage temp.

2-8°C

Quality Level

300

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Application

来自霉菌镰刀菌的伏马菌素B1已被用于：

对从成年猪盲肠内容物中的真菌毒素进行分析的标准品
研究伏马菌素B1对朊病毒蛋白（PrP）异构体的代谢和羊瘙痒病朊病毒蛋白PrP^Sc合成的影响，以及
研究伏马毒素B1对猪空肠外植体的毒性作用。

Biochem/physiol Actions

伏马菌素B1可作为肝致癌物，并在大鼠中引起肝毒性。它在马中会引起白脑脑炎，而在猪中会引起肺水肿综合征。在中国和非洲南部地区，它与人类食道癌的高发有关。它可充当鞘氨醇N-酰基转移酶（神经酰胺合成酶）的抑制剂，这与伏马菌素B1和鞘氨醇碱基（如鞘氨醇）之间的结构相似性有关。

真菌代谢物据信可引起马脑白质软化症。

General description

伏马菌素B1是一种霉菌毒素，存在于许多镰刀菌真菌，例如串珠镰刀菌、层出镰孢菌和拟轮生镰刀菌。这种毒素也存在于被镰刀菌感染的原料和食品，例如玉米。

伏马菌素B1（FB1）与鞘氨醇结构相似。因此，伏马菌素B1可以抑制神经酰胺合成酶（鞘氨醇N-乙酰基转移酶），其可导致神经酰胺生物合成和复杂鞘脂生物合成的中断。

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H351,H361d,H373

pcodes

P202 - P260 - P264 - P280 - P301 + P310 - P405

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2 - Repr. 2 - STOT RE 2

target_organs

Kidney,Liver

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

高风险级别生物产品--毒素类产品

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Deoxynivanelol and fumonisin, alone or in combination, induce changes on intestinal junction complexes and in E-cadherin expression.

Karina Basso et al.

Toxins, 5(12), 2341-2352 (2013-11-30)

Fusariotoxins such as fumonisin B1 (FB1) and deoxynivalenol (DON) cause deleterious effects on the intestine of pigs. The aim of this study was to evaluate the effect of these mycotoxins, alone and in combination, on jejunal explants from piglets, using

Inhibition of Protein Serine/Threonine Phosphatases by Fumonisin B1, a Mycotoxin.

Fukuda H

Biochemical and Biophysical Research Communications, 220, 160-165 (1996)

In vitro microbial metabolism of fumonisin B1.

Judit Fodor et al.

Food additives and contaminants, 24(4), 416-420 (2007-04-25)

There is a lack of information on the effect of swine caecal microbiota on fumonisin metabolism. In this in vitro study, the biotransformation of fumonisin B(1) (FB(1)) by the gut microbiota of adult, healthy pigs was examined. Suspensions of caecal

Visualisation and quantification of fumonisins bound by lactic acid bacteria isolates from traditional African maize-based fermented cereals, ogi and mahewu.

Pranitha Dawlal et al.

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 36(2), 296-307 (2019-01-25)

Consumption of fumonisin-contaminated foods has a negative influence on the health of humans (carcinogen; oesophageal cancer in Eastern Cape in South Africa). Lactic acid bacteria (LAB) have emerged as a promising natural detoxification agent against mycotoxins. The aim of this

The kinetics of urinary fumonisin B1 excretion in humans consuming maize-based diets.

Ronald T Riley et al.

Molecular nutrition & food research, 56(9), 1445-1455 (2012-07-21)

Fumonisins (FB) are mycotoxins found in maize. The purpose of this study was to (i) determine the relationship between FB(1) , FB(2) , and FB(3) intake and urinary excretion in humans, (ii) validate a method to isolate urinary FB on

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Fumonisin B₁

From Fusarium sp. (Fusarium moniliforme), ≥98% (HPLC), ceramide synthase (sphingosine N-acetyltransferase) inhibitor, powder

选择尺寸

关于此项目

主要文件

属性

产品名称

form

SMILES string

InChI

InChI key

biological source

assay

solubility

storage temp.

Quality Level

相关类别

说明

Application

Biochem/physiol Actions

General description

安全信息

pictograms

signalword

hcodes

pcodes

Hazard Classifications

target_organs

存储类别

wgk

flash_point_f

flash_point_c

ppe

法规信息

文件

分析证书(COA)

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