跳转至内容
Merck
CN

F1293

Sigma-Aldrich

非那雄胺

≥98% (HPLC), Selective 5α-reductase inhibitor, powder

别名:

N-叔丁基-3-氧代-4-氮杂-5α-雄甾-1-烯-17β-甲酰胺, MK-906, N-(2-甲基-2-丙基)-3-氧代-4-氮杂-5α-雄甾-1-烯-17β-甲酰胺

登录查看公司和协议定价

选择尺寸

关于此项目

经验公式（希尔记法）:
C23H36N2O2
化学文摘社编号:
98319-26-7
分子量:
372.54
MDL编号:
MFCD00869737
UNSPSC代码:
41116107
PubChem化学物质编号:
24724479
NACRES:
NA.77

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

非那雄胺, ≥98% (HPLC), powder

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: soluble >20 mg/mL

储存温度

room temp

SMILES字符串

[H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](C(=O)NC(C)(C)C)[C@@]4(C)CC[C@]3([H])[C@@]1(C)C=CC(=O)N2

InChI

1S/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18+,22-,23+/m0/s1

InChI key

DBEPLOCGEIEOCV-WSBQPABSSA-N

基因信息

human ... HSD3B1(3283), SRD5A1(6715), SRD5A2(6716)
rat ... Hsd3b1(360348), Srd5a1(24950), Srd5a2(64677)

正在寻找类似产品? 访问 产品对比指南

相关类别

应用

Finasteride has been used:
  • as a component of L-15 media to investigate the effects of finasteride exposure on brain, liver and testis tissues
  • in culture medium to treat tumor cells in vitro
  • as a positive control to treat benign prostatic hyperplasia (BPH)
  • to examine its effect on structural and molecular biology on the ventral prostate of senile mice

生化/生理作用

选择性 5α-还原酶抑制剂；抗雄激素。
Finasteride can reduce serum and scalp dihydrotestosterone (DHT) by preventing the transformation of testosterone to DHT. It is usually used to manage benign prostate hyperplasia and pattern hair loss in male. Finasteride possesses androgen-distracting properties.

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Danger

危险声明

H302,H360FD

危险分类

Acute Tox. 4 Oral - Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

涉药品监管产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000482204
0000482204
0000428024
0000428024
0000348493

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Douglas J Fort et al.
Journal of applied toxicology : JAT, 39(7), 1066-1078 (2019-03-09)
The impact of the perfluoro-chemical, perfluorooctanesulfonate (PFOS), on gonadal steroidogenesis during sexual differentiation in Silurana tropicalis was examined because of its ubiquity in the environment, bioaccumulative nature and potential to disturb endocrine activity. A partial life cycle study exposing S.
Inhibitory effects of Ponciri Fructus on testosterone-induced benign prostatic hyperplasia in rats
Jeon W Y, et al.
BMC Complementary and Alternative Medicine, 17(1), 384-384 (2017)
Finasteride in the treatment of men with androgenetic alopecia
Kaufman K D, et al.
Journal of the American Academy of Dermatology, 39(4), 578-589 (1998)
Yu-Liang Miao et al.
PloS one, 9(7), e101450-e101450 (2014-07-06)
Post-traumatic stress disorder (PTSD) is a debilitating anxiety disorder that may develop after an individual has experienced or witnessed a severe traumatic event. It has been shown that the 18 kDa translocator protein (TSPO) may be correlated with PTSD and
Teemu J Murtola et al.
The Prostate, 73(9), 923-931 (2013-01-22)
Two clinical trials have shown that users of 5α-reductase inhibitors finasteride and dutasteride (5-ARIs) have reduced overall prostate cancer risk, while the proportion of high-grade tumors is increased. We studied tumor characteristics, risk of biochemical recurrence and mortality after radical
查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持