F132
氟西汀 盐酸盐
≥98% (TLC), solid, selective serotonin reuptake inhibitor
别名:
氟西汀 HCl, (±)-N-甲基-γ-[4-(三氟甲基)苯氧基]苯丙胺 盐酸盐, LY-110,140 盐酸盐, Prozac®
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关于此项目
经验公式（希尔记法）:
C17H18F3NO · HCl
化学文摘社编号:
分子量:
345.79
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
氟西汀 盐酸盐, solid
表单
solid
质量水平
颜色
white
溶解性
H2O: 4 mg/mL
DMSO: >5 mg/mL
创始人
Eli Lilly
SMILES字符串
CNCCC(C1=CC=CC=C1)OC2=CC=C(C(F)(F)F)C=C2.[H]Cl
InChI
1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H
InChI key
GIYXAJPCNFJEHY-UHFFFAOYSA-N
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相关类别
一般描述
盐酸氟西汀是一种精神类药物，是最早的抗抑郁药物之一，是选择性血清素再摄取抑制剂。它是百忧解有效成分之一。®
应用
盐酸氟西汀可以用于研究它对于小鼠放射药物 123I-标记2-（（2-（（二甲基氨基）甲基）苯基）硫基）-5-碘苯基胺([123I]ADAM)和SERT（血清素载体）结合的作用。它也被用于长期治疗缺乏光线的动物。它还被用作血清素再摄取抑制剂，以研究其对鱼类急性应激的影响。
生化/生理作用
盐酸氟西汀作用于突触前末梢，它能够避免血清素再摄取，导致突触细胞外液体中血清素积累。
选择性羟色胺再摄取抑制剂；抗抑郁剂。
特点和优势
该化合物是ADME Tox和胞凋亡研究的特色产品。发现更多的ADME Tox和细胞凋亡特色产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
法律信息
经 Eli Lilly and Company 授权销售。
Prozac is a registered trademark of Eli Lilly and Co.
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - STOT RE 2 - STOT SE 3
靶器官
Central nervous system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Maria T Accioly et al.
Cancer research, 68(6), 1732-1740 (2008-03-15)
Lipid bodies (lipid droplets) are emerging as dynamic organelles involved in lipid metabolism and inflammation. Increased lipid body numbers have been described in tumor cells; however, its functional significance in cancer has never been addressed. Here, we showed increased number
Sarah C Wiles et al.
Environmental science & technology, 54(13), 8072-8082 (2020-06-20)
Natural environments are subject to a range of anthropogenic stressors, with pharmaceutical pollution being among the fastest-growing agents of global change. However, despite wild animals living in complex multi-stressor environments, interactions between pharmaceutical exposure and other stressors remain poorly understood.
T Frisan et al.
Blood, 86(4), 1493-1501 (1995-08-15)
Epstein-Barr virus (EBV)-positive Hodgkin's and Reed-Sternberg (HRS) cells express the virus-encoded latent membrane proteins LMP1 and LMP2 that could serve as rejection targets in Hodgkin's disease (HD). To examine whether EBV-triggered reactivities can be detected in the tumor, we have
Murilo S de Abreu et al.
Hormones and behavior, 125, 104813-104813 (2020-07-04)
Stress is known to modulate behavioral responses and rapid decision-making processes, especially under challenging contexts which often occur in social and cooperative interactions. Here, we evaluated the effects of acute stress on cooperative behavior of the Indo-Pacific cleaner wrasse (Labroides
Darlene C Deecher et al.
The Journal of pharmacology and experimental therapeutics, 318(2), 657-665 (2006-05-06)
The purpose of this study was to characterize a new chemical entity, desvenlafaxine succinate (DVS). DVS is a novel salt form of the isolated major active metabolite of venlafaxine. Competitive radioligand binding assays were performed using cells expressing either the
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