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F2293

Follicle Stimulating Hormone from porcine pituitary

Name: Follicle Stimulating Hormone from porcine pituitary
Brand: SIGMA

别名:

FSH, Follitropin, pFSH

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关于此项目

化学文摘社编号:

9002-68-0

UNSPSC Code:

12352209

eCl@ss:

42020504

NACRES:

NA.32

MDL number:

MFCD00131099

Biological source:

Porcine

Form:

powder

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属性

biological source

Porcine

Quality Level

200

form

powder

packaging

pkg of 50 unit per vial

technique(s)

cell culture | mammalian: suitable

solubility

H₂O: soluble 50 mg/mL

UniProt accession no.

P01228, P23945

storage temp.

2-8°C

InChI

1S/C79H125N19O23S/c1-39(2)34-53(90-67(110)51(27-29-57(102)103)87-66(109)49(20-14-15-31-80)86-70(113)54(35-45-18-12-11-13-19-45)92-76(119)63(43(9)99)96-65(108)48(81)38-122)72(115)93-60(40(3)4)75(118)91-55(36-46-23-25-47(101)26-24-46)71(114)88-52(28-30-58(104)105)69(112)97-64(44(10)100)77(120)94-61(41(5)6)74(117)89-50(21-16-32-84-79(82)83)68(111)95-62(42(7)8)78(121)98-33-17-22-56(98)73(116)85-37-59(106)107/h11-13,18-19,23-26,39-44,48-56,60-64,99-101,122H,14-17,20-22,27-38,80-81H2,1-10H3,(H,85,116)(H,86,113)(H,87,109)(H,88,114)(H,89,117)(H,90,110)(H,91,118)(H,92,119)(H,93,115)(H,94,120)(H,95,111)(H,96,108)(H,97,112)(H,102,103)(H,104,105)(H,106,107)(H4,82,83,84)/t43-,44-,48+,49+,50+,51+,52+,53+,54+,55+,56+,60+,61+,62+,63+,64+/m1/s1

InChI key

RPJRYFRWJUYJGY-AYWRSWFDSA-N

Gene Information

human ... FSHR(2492)
pig ... FSHB(396895)

说明

General description

FSH (follicle stimulating hormone) protein is composed of two subunits- α and β, where α subunit has resemblance to LH, hCG and TSH, which are glycoprotein hormones. α subunit has one glycosylation site and β subunit has two.

Application

Follicle stimulating hormone from porcine pituitary has been used for the in vitro maturation, fertilization and co-culture of cumulus oocyte complex and the co-culture of primary germ and Sertoli cells obtained from adult rat testes.

Biochem/physiol Actions

FSH in involved in the growth of ovarian follicles and steroidogenesis of ovaries. FSHR (follicle stimulating hormone receptor) interacts with FSH in the ovaries, and determines the responsiveness to this hormone. Depressed levels of FSHR result in poor responsiveness and influence folliculogenesis. In Caucasian population, certain polymorphisms in this gene are more commonly found in patients with polycystic ovary syndrome (PCOS).

The α-chain is not active; biological specificity is attributed to the β-chain. Induces maturation of Graafian follicles of the ovary; promotes development of germinal cells in males; activates cytosolic tyrosine kinase.

Other Notes

One unit is the activity of 1 mg of Armour FSH Standard G-94 by the method of Steelman, S.L., and Pohley, F.M., Endocrinology, 53, 604 (1953).

Two-chain glycoprotein hormone

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Adding hormones sequentially could be an effective approach for IVM of dog oocytes.

M Evecen et al.

Theriogenology, 75(9), 1647-1651 (2011-03-15)

There have not been successful and repeatable methods for in vitro embryo production in the dog. Up to date, only one blactocyst has been achieved on in vitro culture. Since reproductive physiology of the dog is different from that of

Developmental potential of porcine nuclear transfer embryos derived from transgenic fetal fibroblasts infected with the gene for the green fluorescent protein: comparison of different fusion/activation conditions.

K W Park et al.

Biology of reproduction, 65(6), 1681-1685 (2001-11-22)

The in vitro developmental potential of porcine nuclear transfer (NT) embryos was evaluated. Oocytes were matured for 42-44 h, and metaphase II-oocytes were enucleated. Fetal fibroblasts infected with the enhanced green fluorescent protein (EGFP) gene were serum-starved for 3-5 days.

Prophylactic salpingectomy in premenopausal low-risk women for ovarian cancer: primum non nocere.

Michele Morelli et al.

Gynecologic oncology, 129(3), 448-451 (2013-04-06)

The objective of this study is to compare ovarian function and surgical outcomes between patients affected by benign uterine pathologies submitted to total laparoscopic hysterectomy (TLH) plus salpingectomy and women in which standard TLH with adnexal preservation was performed. We

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货号	GTIN
F2293-1VL	04061833612873
F2293-5VL	04061833612880