F2379
胎球蛋白 from fetal bovine serum
lyophilized powder, suitable for cell culture
别名:
胎球蛋白 from fetal bovine serum, 胎球蛋白 来源于胎牛血清
biological source
bovine serum (fetal)
form
lyophilized powder
technique(s)
cell culture | mammalian: suitable
impurities
≤0.3% free N-acetylneuraminic acid
solubility
H2O: 1 mg/mL, colorless to faint yellow or tan
UniProt accession no.
storage temp.
2-8°C
Quality Level
Gene Information
bovine ... FETUA(504615)
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General description
Fetuin from fetal bovine serum is a 64 kDa plasma glycoprotein. It is produced by the liver and adipose tissue.
Application
Fetuin from fetal bovine serum has been used:
- to synthesize primary and secondary calciprotein particles (CPP)
- to study the binding of Xerocomus chrysenteron lectin (XCL) to the T antigen expressed by membrane proteins
- as a supplement in Ham′s F10 media for myoblast culture.
Fetuin is a protein with the ability to bind to the insulin receptor and inhibit insulin action. Fetuin has been used in studies of type 2 diabetes mellitus (T2DM). In patients with T2DM, fetuin has been shown to be significantly lower when compared to control patients. Fetuin has also been used in studies to demonstrate its protective role in the development of arterial calcification.
Biochem/physiol Actions
Fetuin, an inhibitor of insulin receptor tyrosine kinase, modulates bone remodeling and calcium metabolism. It is involved in keratinocytes migration and breast tumor cell proliferative signaling. Fetuin also regulates vascular calcification, insulin resistance and protease activity It acts as a biomarker for neurodegenerative diseases. Fetuin has anti-inflammatory property.
Preparation Note
Prepared by ammonium sulfate fractionation of fetal calf serum by the method of Pederson, K.O., J. Phys. and Colloid Chem., 51, 164 (1947).
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
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