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文件

安全信息

F2427

Sigma-Aldrich

Fluprostenol isopropyl ester

≥98%, ethanol solution

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别名:
(±)-16-(m-Trifluoromethylphenoxy)tetranorprostaglandin F2, Travoprost
经验公式（希尔记法）:
C26H35F3O6
CAS号:
157283-68-6
分子量:
500.55
EC 号:
200-578-6
MDL编号:
MFCD03411995
PubChem化学物质编号:
329799691
NACRES:
NA.77

质量水平

200

检测方案

≥98%

形式

ethanol solution

运输

wet ice

储存温度

−20°C

SMILES字符串

CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)COc2cccc(c2)C(F)(F)F

InChI

1S/C26H35F3O6/c1-17(2)35-25(33)11-6-4-3-5-10-21-22(24(32)15-23(21)31)13-12-19(30)16-34-20-9-7-8-18(14-20)26(27,28)29/h3,5,7-9,12-14,17,19,21-24,30-32H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12+/t19-,21-,22-,23+,24-/m1/s1

InChI key

MKPLKVHSHYCHOC-AHTXBMBWSA-N

基因信息

human ... PTGFR(5737)

生化/生理作用

Potent FP prostanoid receptor agonist used in animal models for glaucoma.

象形图

FlameExclamation mark
GHS02,GHS07

警示用语：

Danger

危险声明

H225 - H319

危险分类

Eye Irrit. 2 - Flam. Liq. 2

储存分类代码

3 - Flammable liquids

WGK

WGK 2

闪点(°F)

62.6 °F - closed cup

闪点(°C)

17 °C - closed cup

法规信息

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Takashi Kanamoto et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 31(3), 156-164 (2015-02-25)
To evaluate some clinically important features of benzalkonium chloride (BAK) toxicity by comparing tafluprost with 0.001% BAK and travoprost preserved with SofZia applied to the ocular surface of the eyes with glaucoma. This was a prospective, randomized, observer unmasked, multicenter
Chengpu Zhang
Pakistan journal of pharmaceutical sciences, 28(2 Suppl), 781-784 (2015-03-23)
This study discussed about the influence of local application of glaucoma medications -- travoprost eye drops to patients' tear film function. We selected 24 patients, 45 eyes with primary open-angle glaucoma or intraocular hypertension. All of the patients topically used
Shinsaku Yamane et al.
Investigative ophthalmology & visual science, 56(4), 2547-2552 (2015-03-20)
The purpose of this study was to determine whether a better IOP reduction can be observed in conscious, normotensive monkeys treated with ONO-9054, a novel dual EP3 and FP receptor agonist, compared with prostaglandin F2α analogs. The binding affinities and
Joao F Lopes et al.
BMC ophthalmology, 15, 166-166 (2015-11-14)
Prostaglandin analogs reduce intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension; however, these medications may affect the ocular surface and elicit ocular discomfort when preserved with benzalkonium chloride (BAK). This was an open-label, single-arm study conducted in
Anastasios G P Konstas et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 29(7), 652-657 (2013-04-05)
To determine the adjunctive 24-h efficacy obtained with brinzolamide/timolol, or brimonidine/timolol fixed combinations (FCs) in open-angle glaucoma patients insufficiently controlled on travoprost monotherapy. Prospective, observer-masked, active controlled, crossover, comparison. Qualified primary open-angle or exfoliative glaucoma patients with a baseline intraocular
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