F2802
伏氟沙明马来酸盐
neuronal serotonin reuptake inhibitor, solid
别名:
(E)-5-甲氧基-1-(4-三氟甲苯基)-1-戊酮-O-(2-胺乙肟基)-马来酸盐
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关于此项目
经验公式(希尔记法):
C15H21F3N2O2 · C4H4O4
CAS Number:
分子量:
434.41
MDL编号:
UNSPSC代码:
12352116
PubChem化学物质编号:
NACRES:
NA.77
Product Name
伏氟沙明马来酸盐, solid
表单
solid
质量水平
溶解性
H2O: soluble
创始人
Solvay
储存温度
2-8°C
SMILES字符串
COCCCC/C(C1=CC=C(C(F)(F)F)C=C1)=N\OCCN.OC(/C=C\C(O)=O)=O
InChI
1S/C15H21F3N2O2.C4H4O4/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18;5-3(6)1-2-4(7)8/h5-8H,2-4,9-11,19H2,1H3;1-2H,(H,5,6)(H,7,8)/b20-14+;2-1-
InChI key
LFMYNZPAVPMEGP-PIDGMYBPSA-N
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相关类别
应用
马来酸氟伏沙明已被用作测试化合物用于测定溶解度和有效血脑屏障通透性。(2)
生化/生理作用
马来酸氟伏沙明是一种选择性的神经元5-羟色胺再摄取抑制剂。它可发挥抗抑郁和抗强迫症药物的作用。它可用于治疗强迫症和惊恐障碍。
特点和优势
该化合物收录于 受体分类和信号转导手册的《生物胺转运体 》页面。想要浏览手册的其他页面, 请单击此处。
这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
警示用语:
Warning
危险声明
预防措施声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Mosby's Drug Reference for Health Professions null
Md Shenuarin Bhuiyan et al.
Journal of pharmacological sciences, 121(3), 177-184 (2013-02-23)
Depression is associated with a substantial increase in the risk of developing heart failure and is independently associated with increased cardiovascular morbidity and mortality. Inversely, cardiovascular disease can lead to severe depression. Thus, therapy with selective serotonin reuptake inhibitors (SSRIs)
M Inazu et al.
Neurochemistry international, 39(1), 39-49 (2001-04-20)
Astrocytes contain transport systems that are capable of removing various neurotransmitters from the synaptic cleft by transporters present in the plasma membrane. Glial serotonin transporter (SERT) plays an important role in the re-uptake of 5-hydroxytryptamine (5-HT). We examined the pharmacological
John Lekakis et al.
International journal of cardiology, 139(2), 150-158 (2008-11-14)
Selective serotonin reuptake inhibitors (SSRIs) exert cardioprotective effects. We examined whether SSRIs a) modulate endothelial cell expression of vascular cell adhesion molecule (VCAM-1), intracellular adhesion molecule (ICAM-1) and adhesiveness to U937 monocytes, b) reduce the circulating levels of these adhesion
Anton J L M van Balkom et al.
Psychotherapy and psychosomatics, 81(6), 366-374 (2012-09-12)
To compare the effectiveness of second-step treatment with cognitive therapy (CT) versus fluvoxamine in patients with obsessive-compulsive disorder (OCD) who are nonresponsive to exposure in vivo with response prevention (ERP). A 12-week randomized controlled trial at an outpatient clinic in
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