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F2802

伏氟沙明马来酸盐

Name: 伏氟沙明马来酸盐
Brand: SIGMA

neuronal serotonin reuptake inhibitor, solid

别名:

(E)-5-甲氧基-1-(4-三氟甲苯基)-1-戊酮-O-(2-胺乙肟基)-马来酸盐

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关于此项目

经验公式（希尔记法）:

C₁₅H₂₁F₃N₂O₂ · C₄H₄O₄

化学文摘社编号:

61718-82-9

分子量:

434.41

UNSPSC Code:

12352116

PubChem Substance ID:

24278162

NACRES:

NA.77

MDL number:

MFCD00269809

Form:

solid

Quality level:

200

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产品名称

伏氟沙明马来酸盐, solid

form

solid

Quality Level

200

solubility

H₂O: soluble

originator

Solvay

storage temp.

2-8°C

SMILES string

COCCCC/C(C1=CC=C(C(F)(F)F)C=C1)=N\OCCN.OC(/C=C\C(O)=O)=O

InChI

1S/C15H21F3N2O2.C4H4O4/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18;5-3(6)1-2-4(7)8/h5-8H,2-4,9-11,19H2,1H3;1-2H,(H,5,6)(H,7,8)/b20-14+;2-1-

InChI key

LFMYNZPAVPMEGP-PIDGMYBPSA-N

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363), SLC6A4(6532)

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Application

马来酸氟伏沙明已被用作测试化合物用于测定溶解度和有效血脑屏障通透性。（2）

Biochem/physiol Actions

马来酸氟伏沙明是一种选择性的神经元5-羟色胺再摄取抑制剂。它可发挥抗抑郁和抗强迫症药物的作用。它可用于治疗强迫症和惊恐障碍。

Features and Benefits

该化合物由Solvay开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。

这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

该化合物收录于受体分类和信号转导手册的《生物胺转运体》页面。想要浏览手册的其他页面，请单击此处。

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000472208

0000468273

0000468272

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Mosby's Drug Reference for Health Professions null

In silico and intuitive predictions of CYP46A1 inhibition by marketed drugs with subsequent enzyme crystallization in complex with fluvoxamine.

Natalia Mast et al.

Molecular pharmacology, 82(5), 824-834 (2012-08-04)

Cytochrome P450 46A1 (cholesterol 24-hydroxylase) is an important brain enzyme that may be inhibited by structurally distinct pharmaceutical agents both in vitro and in vivo. To identify additional inhibitors of CYP46A1 among U.S. Food and Drug Administration-approved therapeutic agents, we

Acute and sustained effects of a metabotropic glutamate 5 receptor antagonist in the novelty-suppressed feeding test.

Michihiko Iijima et al.

Behavioural brain research, 235(2), 287-292 (2012-08-28)

Accumulated evidence indicates that metabotropic glutamate 5 (mGlu5) receptor blockade exerts antidepressant-like and anxiolytic-like effects in several animal models. The novelty-suppressed feeding (NSF) test is used to measure anxiety-induced hypophagia in rodents. Anxiogenic-like behavior can be counteracted by acute treatment

A preliminary study of fluvoxamine maleate on depressive state and serum melatonin levels in patients after cerebral infarction.

Eiko Sunami et al.

Internal medicine (Tokyo, Japan), 51(10), 1187-1193 (2012-06-13)

Antidepressants have been recommended for the treatment of post-stroke depression (PSD). The purpose of this study was to evaluate the effect of fluvoxamine maleate, a selective serotonin re-uptake inhibitor (SSRI), on depressive state, sleep disturbance, and serum melatonin levels in

Crucial interactions between selective serotonin uptake inhibitors and sigma-1 receptor in heart failure.

Md Shenuarin Bhuiyan et al.

Journal of pharmacological sciences, 121(3), 177-184 (2013-02-23)

Depression is associated with a substantial increase in the risk of developing heart failure and is independently associated with increased cardiovascular morbidity and mortality. Inversely, cardiovascular disease can lead to severe depression. Thus, therapy with selective serotonin reuptake inhibitors (SSRIs)

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货号	GTIN
F2802-10MG	04061833613320
F2802-50MG	04061832082073

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