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Merck
CN

F3261

[Glu1]-纤维蛋白肽B 人

≥90% (HPLC)

别名:

Fibrinopeptide B

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关于此项目

经验公式（希尔记法）:
C66H95N19O26
化学文摘社编号:
103213-49-6
分子量:
1570.57
NACRES:
NA.32
PubChem Substance ID:
329799697
UNSPSC Code:
12352202
MDL number:
MFCD00076440
Form:
powder
Assay:
≥90% (HPLC)
Biological source:
human

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InChI

1S/C66H95N19O26/c1-31(2)53(85-48(90)29-73-55(100)35(67)16-19-49(91)92)64(109)83-42(26-46(69)88)61(106)82-43(27-52(97)98)62(107)81-41(25-45(68)87)60(105)78-37(18-21-51(95)96)57(102)77-36(17-20-50(93)94)56(101)74-28-47(89)76-39(23-33-11-6-4-7-12-33)58(103)80-40(24-34-13-8-5-9-14-34)59(104)84-44(30-86)63(108)75-32(3)54(99)79-38(65(110)111)15-10-22-72-66(70)71/h4-9,11-14,31-32,35-44,53,86H,10,15-30,67H2,1-3H3,(H2,68,87)(H2,69,88)(H,73,100)(H,74,101)(H,75,108)(H,76,89)(H,77,102)(H,78,105)(H,79,99)(H,80,103)(H,81,107)(H,82,106)(H,83,109)(H,84,104)(H,85,90)(H,91,92)(H,93,94)(H,95,96)(H,97,98)(H,110,111)(H4,70,71,72)/t32-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,53-/m0/s1

SMILES string

CC(C)[C@H](NC(=O)CNC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChI key

KPBJTGOVJLITON-OECXYHNASA-N

biological source

human

assay

≥90% (HPLC)

form

powder

technique(s)

LC/MS: suitable, electrophoresis: suitable

UniProt accession no.

P02675

storage temp.

−20°C

Quality Level

200

Gene Information

human ... FGB(2244)

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General description

纤维蛋白肽B （FPB）是在纤维蛋白原被凝血酶裂解为纤维蛋白单体的过程中产生的。它被从纤维蛋白原的氮端& # 946；链切割下来。这种肽由14个氨基酸组成。

Application

[Glu1]-纤维蛋白肽B人类已被用于：
  • LC-MS过程，避免交叉污染并分析质谱仪和LC仪器的性能
  • 用于2D（维）凝胶电泳期间的两点校准和通过质谱鉴定从耻垢分枝杆菌分离的组氨酸（his）-Pup（原核泛素样蛋白）的蛋白质鉴定
  • 用于一维凝胶电泳和串联质谱期间的两点校准，以表征从电气杆菌唾液腺匀浆中获得的可溶性蛋白质样品
  • 作为从胰蛋白酶消化蛋白质二硫键异构酶（PDI）获得的肽上进行的MS和MS / MS获得的数据校正质量漂移的标准

Biochem/physiol Actions

纤维蛋白的形成是伤口愈合和炎症的重要因素。纤维蛋白肽B （FPB）也能引起中性粒细胞趋化迁移，而不同时释放溶酶体酶。它是在纤维蛋白原凝固过程中产生的，纤维蛋白原对生理体内平衡至关重要。它涉及各种疾病，如血栓形成和弥散性血管内凝血。

Other Notes

从0.1％TFA水溶液中冻干

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000504425
0000504425
0000218055
0000459204
0000459204

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