Merck
CN

F3917

Sigma-Aldrich

毛喉素

For use in molecular biology applications

登录查看公司和协议定价

别名:
7β-乙酰氧基-1α,6β,9α-二羟基-8,13-环氧-半日花-14-EN-11-酮, 洋紫苏醇, 考福新
经验公式(希尔记法):
C22H34O7
CAS号:
分子量:
410.50
Beilstein:
1692716
EC 号:
MDL编号:
PubChem化学物质编号:

生物来源

Coleus forskohlii

质量水平

描述

for activation of T cells

产品线

BioReagent

检测方案

≥98% (HPLC)

形式

powder

分子量

410.50  g/mol

颜色

white to off-white

溶解性

ethanol: soluble

适用性

suitable for inhibits interleukin 2 (IL-2) production in Jurkat cells

储存温度

room temp

SMILES字符串

CC(=O)O[C@H]1[C@@H](O)[C@H]2C(C)(C)CC[C@H](O)[C@]2(C)[C@@]3(O)C(=O)C[C@@](C)(O[C@]13C)C=C

InChI

1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1

InChI key

OHCQJHSOBUTRHG-KGGHGJDLSA-N

正在寻找类似产品? Visit 产品对比指南

一般描述

毛喉素是从Coleus forskohlii分离提取的细胞渗透双萜。

生化/生理作用

具有抗高血压、正性变力作用和腺苷酸环化酶活化特性的细胞通透性二萜类化合物。它的许多生物学作用是由于其对腺苷酸环化酶的激活以及由此而导致的细胞内cAMP浓度增加。毛喉素可影响钙电流并抑制MAP激酶。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Dermal

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

为方便起见,与您过往购买产品相关的文件已保存在文档库中。

访问文档库

难以找到您所需的产品或批次号码?

在网站页面上,产品编号会附带包装尺寸/数量一起显示(例如:T1503-25G)。请确保 在“产品编号”字段中仅输入产品编号 (示例: T1503).

示例

T1503
货号
-
25G
包装规格/数量

其它示例:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

遇到问题?欢迎随时联系我们技术服务 寻求帮助

批号可以在产品标签上"批“ (Lot或Batch)字后面找到。

Aldrich 产品

  • 如果您查询到的批号为 TO09019TO 等,请输入去除前两位字母的批号:09019TO。

  • 如果您查询到的批号含有填充代码(例如05427ES-021),请输入去除填充代码-021的批号:05427ES。

  • 如果您查询到的批号含有填充代码(例如 STBB0728K9),请输入去除填充代码K9的批号:STBB0728。

未找到您寻找的产品?

部分情况下,可能未在线提供COA。如果搜索不到COA,可在线索取。

索取COA

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. How should I store a DMSO or ethanol solution of Product F3917, Forskolin?

    Forskolin solutions at 5 mg/mL in either ethanol or DMSO have been found to be stable for at least 6 months at room temperature, as determined by HPLC analysis.

  6. How can I make an aqueous solution of Product F3917, Forskolin?

    Forskolin is soluble in water (with 2% ethanol) up to 0.2 mM by first dissolving in ethanol at 5 mg/mL and performing subsequent dilutions in water. Similar results were obtained with DMSO.

  7. Will residual solvents inhibit forskolin activation of adenylate cyclase?

    Various solvents, including ethanol, inhibit the forskolin activation of adenylate cyclase. DMSO is recommended for preparing forskolin solutions, because at concentrations of 5% or less of DMSO, there is little if any inhibition of forskolin activation.

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

A Ramón-Cueto et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 18(10), 3803-3815 (1998-06-06)
The lack of axonal regeneration in the injured adult mammalian spinal cord leads to permanent functional impairment. To induce axonal regeneration in the transected adult rat spinal cord, we have used the axonal growth-promoting properties of adult olfactory bulb ensheathing
Jin Wei Chung et al.
Biology of reproduction, 86(3), 80-80 (2011-12-03)
The signaling molecule DHH, secreted by Sertoli cells, has essential regulatory functions in testicular differentiation. DHH is required for the differentiation of peritubular myoid cells that line the seminiferous cords and steroidogenic Leydig cells. The testicular cords in Dhh-null male
T Marchetti et al.
Journal of thrombosis and haemostasis : JTH, 12(6), 910-920 (2014-03-25)
Obstetric antiphospholipid syndrome (APS) is defined by pregnancy complications associated with antiphospholipid antibodies (aPL). The mechanisms of the pathogenic effects of aPL in pregnancy are poorly understood. Toll-like receptors (TLR) have been implicated previously in APS. The aims of our
Koji Yokoyama et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(1), 302-314 (2014-10-11)
Neonatal-onset multisystem inflammatory disease (NOMID) is a dominantly inherited autoinflammatory disease caused by NLRP3 mutations. NOMID pathophysiology is explained by the NLRP3 inflammasome, which produces interleukin-1β (IL-1β). However, epiphyseal overgrowth in NOMID is resistant to anti-IL-1 therapy and may therefore
Jeanne Ster et al.
The Journal of physiology, 587(1), 101-113 (2008-11-13)
Extensive work has shown that activation of the cAMP-dependent protein kinase A (PKA) is crucial for long-term depression (LTD) of synaptic transmission in the hippocampus, a phenomenon that is thought to be involved in memory formation. Here we studied the

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门