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安全信息

F3929

Sigma-Aldrich

Anti-Follicle-Stimulating Hormone Receptor antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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别名:
Anti-FSHR
MDL编号:
MFCD00162296
NACRES:
NA.41

生物来源

rabbit

质量水平

200

偶联物

unconjugated

抗体形式

affinity isolated antibody

antibody product type

primary antibodies

克隆

polyclonal

形式

buffered aqueous solution

species reactivity

human

availability

not available in Japan

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 7-14 μg/mL

UniProt登记号

P23945

运输

dry ice

储存温度

−20°C

target post-translational modification

unmodified

Gene Information

human ... FSHR(2492)
mouse ... Fshr(14309)
rat ... Fshr(25449)

一般描述

Follicle stimulating hormone receptor (FSHR) belongs to the G protein-coupled receptors family and is a glycoprotein. FSHR gene is mapped to human chromosome 2p16.3. FSHR comprises hydrophilic domain, hydrophobic membrane regions, C-terminal extracellular domain, and short intracellular domain.

免疫原

synthetic peptide coresponding to the N-terminal extracellular domain of human follicle-stimulating hormone receptor, conjugated to KLH. The immunizing peptide has 24% identity and 29% similarity with the mouse gene.

应用

Anti-Follicle-Stimulating Hormone Receptor antibody produced in rabbit has also been used in immunohistochemistry in ovine and reproductive tissues. It has also been used in western blotting.

生化/生理作用

Follicle stimulating hormone receptor (FSHR) is located on Sertoli cells of the testes and the granulosa cells of ovary. The pituitary glycoprotein hormone, FSH, binds to FSHR and regulates the function of gonads and overall fertility. In Sertoli cells, FSHR-mediated cell proliferation determines the spermatogenic output. In ovarian granulosa cells, FSHR signaling mediates follicular growth and maturation of oocytes. Polymorphisms in the FSHR is implicated in premature ovarian insufficiency.

外形

Solution in phosphate buffered saline containing 0.1% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

10 - Combustible liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

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Leslie L Heckert et al.
Recent progress in hormone research, 57, 129-148 (2002-05-23)
Results from experiments using mouse models suggest that the role of follicle-stimulating hormone (FSH) in spermatogenesis is the regulation of Sertoli cell proliferation and, ultimately, the size and spermatogenic capacity of the testis. The regulation of the expression of the
Lingyuan Fu et al.
Journal of assisted reproduction and genetics, 30(5), 717-721 (2013-03-29)
Polycystic ovary syndrome (PCOS) is a common complex genetic endocrinopathy. It has high heritability, and twin studies indicate that it is a complex polygenic disorder. Searching for major genes of PCOS is crucial to clarify its molecular pathogenesis. A previous
The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology.
M Simoni et al.
Endocrine reviews, 18(6), 739-773 (1997-12-31)
Jitu W George et al.
Biology of reproduction, 84(1), 7-17 (2010-08-27)
Follicle-stimulating hormone (FSH), a pituitary glycoprotein hormone, is an integral component of the endocrine axis that regulates gonadal function and fertility. To transmit its signal, FSH must bind to its receptor (FSHR) located on Sertoli cells of the testis and
A T Grazul-Bilska et al.
Domestic animal endocrinology, 71, 106391-106391 (2019-11-16)
Corpus luteum (CL), a transient endocrine gland critical for reproductive cyclicity and pregnancy maintenance, is controlled by numerous regulatory factors. Although LH is widely recognized as the major regulator, other factors may also affect luteal functions. It has been demonstrated
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