主要文件

查看所有文档

F4381

呋塞米

Name: 呋塞米
Brand: SIGMA

≥98% (HPLC), powder, NKCC symporter inhibitor

别名:

4-氯-N-呋喃基-5-氨磺酰邻氨基苯甲酸, 5-(氨基磺酰基)-4-氯-2-([2-呋喃甲基]氨基)苯甲酸

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₁₂H₁₁ClN₂O₅S

化学文摘社编号:

54-31-9

分子量:

330.74

NACRES:

NA.77

PubChem Substance ID:

24277714

UNSPSC Code:

12352200

EC Number:

200-203-6

MDL number:

MFCD00010549

Assay:

≥98% (HPLC)

Form:

powder

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

产品名称

呋塞米,

biological source

synthetic (organic)

Quality Segment

200

assay

≥98% (HPLC)

form

powder

mp

220 °C (dec.) (lit.)

solubility

acetone: 50 mg/mL, clear to slightly hazy, colorless to yellow

originator

Sanofi Aventis

storage temp.

room temp

SMILES string

NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl

InChI

1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)

InChI key

ZZUFCTLCJUWOSV-UHFFFAOYSA-N

Gene Information

human ... ALB(213), CYP1A2(1544), SLC12A1(6557)

说明

General description

Furosemide is a an ototoxic high-ceiling diuretic.

Application

Furosemide has been used:

to investigate the influence of timing of dexamethasone administration on auditory hair cell survival in mice
to study its effect on intracranial pressure (ICP) after subcutaneous administration in rats
as a stimulant for renin release and subsequent increase in plasma angiotensin II (ANG II)

Biochem/physiol Actions

Furosemide can block the Na⁺/K⁺/2Cl^- co-transporter in the ascending thick loop of Henle. It can enhance the synthesis of intrarenal prostaglandin. It enhances its ototoxicity in animals when used along with kanamycin. Furosemide is linked with thiamine insufficiency in individuals with heart failure.

"High ceiling" diuretic that strongly affects renal tubular action by increasing renal blood flow; antihypertensive.

抑制肾脏中离子的协同运输。

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Still not finding the right product?

Explore all of our products under 呋塞米

pictograms

GHS08,GHS07

signalword

Danger

hcodes

H302,H360FD

pcodes

P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

新产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

商品

Discover Bioactive Small Molecules for ADME/Tox

全球贸易项目编号

货号	GTIN
F4381-5G	04061832574486
F4381-1G	04061833617694
F4381-10G	04061833617687
F4381-25G	04061832574479