F4381
呋塞米
≥98% (HPLC), powder, NKCC symporter inhibitor
别名:
4-氯-N-呋喃基-5-氨磺酰邻氨基苯甲酸, 5-(氨基磺酰基)-4-氯-2-([2-呋喃甲基]氨基)苯甲酸
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关于此项目
经验公式（希尔记法）:
C12H11ClN2O5S
化学文摘社编号:
分子量:
330.74
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-203-6
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
产品名称
呋塞米,
biological source
synthetic (organic)
Quality Segment
assay
≥98% (HPLC)
form
powder
mp
220 °C (dec.) (lit.)
solubility
acetone: 50 mg/mL, clear to slightly hazy, colorless to yellow
originator
Sanofi Aventis
storage temp.
room temp
SMILES string
NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl
InChI
1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)
InChI key
ZZUFCTLCJUWOSV-UHFFFAOYSA-N
Gene Information
human ... ALB(213), CYP1A2(1544), SLC12A1(6557)
General description
Furosemide is a an ototoxic high-ceiling diuretic.
Application
Furosemide has been used:
- to investigate the influence of timing of dexamethasone administration on auditory hair cell survival in mice
- to study its effect on intracranial pressure (ICP) after subcutaneous administration in rats
- as a stimulant for renin release and subsequent increase in plasma angiotensin II (ANG II)
Biochem/physiol Actions
Furosemide can block the Na+/K+/2Cl- co-transporter in the ascending thick loop of Henle. It can enhance the synthesis of intrarenal prostaglandin. It enhances its ototoxicity in animals when used along with kanamycin. Furosemide is linked with thiamine insufficiency in individuals with heart failure.
"High ceiling" diuretic that strongly affects renal tubular action by increasing renal blood flow; antihypertensive.
抑制肾脏中离子的协同运输。
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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警示词
Danger
危险代码
Hazard Classifications
Acute Tox. 4 Oral - Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
怎么回事？
WGK 2
闪点 (F)
Not applicable
闪点 (°C)
Not applicable
PPE（个人防护设备）
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges