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Merck
CN

F4381

Sigma-Aldrich

呋塞米

≥98% (HPLC), powder, NKCC symporter inhibitor

别名:

4-氯-N-呋喃基-5-氨磺酰邻氨基苯甲酸, 5-(氨基磺酰基)-4-氯-2-([2-呋喃甲基]氨基)苯甲酸

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关于此项目

经验公式（希尔记法）:
C12H11ClN2O5S
化学文摘社编号:
54-31-9
分子量:
330.74
EC 号:
200-203-6
MDL编号:
MFCD00010549
UNSPSC代码:
12352200
PubChem化学物质编号:
24277714
NACRES:
NA.77

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产品名称

呋塞米,

生物来源

synthetic (organic)

质量水平

200

方案

≥98% (HPLC)

表单

powder

mp

220 °C (dec.) (lit.)

溶解性

acetone: 50 mg/mL, clear to slightly hazy, colorless to yellow

创始人

Sanofi Aventis

储存温度

room temp

SMILES字符串

NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl

InChI

1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)

InChI key

ZZUFCTLCJUWOSV-UHFFFAOYSA-N

基因信息

human ... ALB(213), CYP1A2(1544), SLC12A1(6557)

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相关类别

一般描述

Furosemide is a an ototoxic high-ceiling diuretic.

应用

Furosemide has been used:
  • to investigate the influence of timing of dexamethasone administration on auditory hair cell survival in mice
  • to study its effect on intracranial pressure (ICP) after subcutaneous administration in rats
  • as a stimulant for renin release and subsequent increase in plasma angiotensin II (ANG II)

生化/生理作用

"High ceiling" diuretic that strongly affects renal tubular action by increasing renal blood flow; antihypertensive.
抑制肾脏中离子的协同运输。
Furosemide can block the Na+/K+/2Cl- co-transporter in the ascending thick loop of Henle. It can enhance the synthesis of intrarenal prostaglandin. It enhances its ototoxicity in animals when used along with kanamycin. Furosemide is linked with thiamine insufficiency in individuals with heart failure.

特点和优势

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Danger

危险声明

H302,H360FD

危险分类

Acute Tox. 4 Oral - Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

新产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCZ2659
MKCW8108
MKCW1211
MKCV0415
MKCV0326

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Development of an ototoxicity model in the adult CBA/CaJ mouse and determination of a golden window of corticosteroid intervention for otoprotection
Fernandes V T and Lin V YW
Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'Oto-rhino-laryngologie et de Chirurgie Cervico-Faciale, 43(1), 12-12 (2014)
Furosemide
Saunders Handbook of Veterinary Drugs - E-Book (2016)
Causes of acquired hearing loss
Eggermont J J
Hearing Loss: Causes, Prevention, and Treatment (2017)
Topiramate is more effective than acetazolamide at lowering intracranial pressure
Scotton W J, et al.
Cephalalgia, 0333102418776455-0333102418776455 (2018)
Diuretics
Side Effects of Drugs Annual, 28, 233-243 (2005)
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