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Merck
CN

F4765

盐酸氟奋乃静 二盐酸盐

别名:

4- [3- [2-(三氟甲基)-10H-吩噻嗪-10-基]丙基] -1-哌嗪乙醇 二盐酸盐

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关于此项目

经验公式(希尔记法):
C22H26F3N3OS · 2HCl
化学文摘社编号:
分子量:
510.44
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
205-674-1
MDL number:
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SMILES string

Cl.Cl.OCCN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1

InChI

1S/C22H26F3N3OS.2ClH/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29;;/h1-2,4-7,16,29H,3,8-15H2;2*1H

InChI key

MBHNWCYEGXQEIT-UHFFFAOYSA-N

Gene Information

General description

Fluphenazine may be useful for the treatment of schizophrenia.

Application

Fluphenazine dihydrochloride has been used:
  • to study its effects as a drug on glioblastoma (GBM) cells
  • in fluorescence-activated cell sorting (FACS) analysis, sorting and single-cell stress-survival experiments
  • to study its exposure effects on learning and memory in adult rats

Biochem/physiol Actions

D1/D2多巴胺受体拮抗剂;吩噻嗪类抗精神病药;H1组胺受体拮抗剂。


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pictograms

Skull and crossbonesHealth hazard

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral - Repr. 1A

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

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Principles of Psychopharmacology for Mental Health Professionals (2006)
Coupling phenotypic persistence to DNA damage increases genetic diversity in severe stress
Yaakov G, et al.
Nature ecology & evolution, 1(1), 0016-0016 (2017)
G Cai et al.
Molecular pharmacology, 56(5), 989-996 (1999-10-26)
The interaction of dopaminergic antagonists with the D(1A) dopamine receptor was assessed in PC2 cells that transiently express this receptor. The maximal binding and dissociation constants for the D(1A) dopamine receptor, using the ligand [(125)I]SCH23982 were 0.38 +/- 0.09 nM



全球贸易项目编号

货号GTIN
F4765-5G04061832090832
F4765-1G04061825982250