F4765
盐酸氟奋乃静 二盐酸盐
别名:
4- [3- [2-（三氟甲基）-10H-吩噻嗪-10-基]丙基] -1-哌嗪乙醇 二盐酸盐
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关于此项目
经验公式（希尔记法）:
C22H26F3N3OS · 2HCl
化学文摘社编号:
分子量:
510.44
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
205-674-1
MDL number:
InChI key
MBHNWCYEGXQEIT-UHFFFAOYSA-N
InChI
1S/C22H26F3N3OS.2ClH/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29;;/h1-2,4-7,16,29H,3,8-15H2;2*1H
SMILES string
Cl.Cl.OCCN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1
Gene Information
human ... DRD1(1812), DRD2(1813), HRH1(3269)
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General description
Fluphenazine may be useful for the treatment of schizophrenia.
Application
Fluphenazine dihydrochloride has been used:
- to study its effects as a drug on glioblastoma (GBM) cells
- in fluorescence-activated cell sorting (FACS) analysis, sorting and single-cell stress-survival experiments
- to study its exposure effects on learning and memory in adult rats
Biochem/physiol Actions
D1/D2多巴胺受体拮抗剂；吩噻嗪类抗精神病药；H1组胺受体拮抗剂。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Repr. 1A
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
G Cai et al.
Molecular pharmacology, 56(5), 989-996 (1999-10-26)
The interaction of dopaminergic antagonists with the D(1A) dopamine receptor was assessed in PC2 cells that transiently express this receptor. The maximal binding and dissociation constants for the D(1A) dopamine receptor, using the ligand [(125)I]SCH23982 were 0.38 +/- 0.09 nM
Coupling phenotypic persistence to DNA damage increases genetic diversity in severe stress
Yaakov G, et al.
Nature ecology & evolution, 1(1), 0016-0016 (2017)
Principles of Psychopharmacology for Mental Health Professionals (2006)
The Effect of Intrauterine Antipsychotic Drug Exposure on Learning and Memory in Adult Rats
Oltulu C and Karadag CH
Klinik Psikofarmakoloji Bulteni-Bulletin of Clinical Psychopharmacology, 26(4), 364-373 (2016)
Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data
Cheng HW, et al.
Cell Death & Disease, 6(5), e1753-e1753 (2015)
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