Quality Level
assay
≥85% (HPLC)
form
powder
mp
163-180 °C
solubility
methanol: 9.80-10.20 mg/mL, clear, colorless to yellow
antibiotic activity spectrum
fungi, yeast
mode of action
cell membrane | interferes
storage temp.
−20°C
SMILES string
CCCCCC(O)C1C(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)C(C)=C\C=C\C=C\C=C\C=C\C(O)C(C)OC1=O
InChI
1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14-
InChI key
IMQSIXYSKPIGPD-BWJOQPJXSA-N
Application
在双重染色实验中，菲律平蛋白可用作探针，检测聚丙烯酰胺凝胶中及固定在硝酸纤维素膜上的脂蛋白。
在双重染色实验中，菲律平蛋白可用作探针，检测聚丙烯酰胺凝胶中及固定在硝酸纤维素膜上的脂蛋白。借助特定的荧光复合物，这一物质还广泛用于定位和定量未酯化的胆固醇。
Biochem/physiol Actions
菲律平是一种多烯大环内酯类抗生素和抗真菌药。抗真菌作用机制可能是由于通过结合膜固醇改变了膜的渗透性和相关的功能。菲律平可抑制朊蛋白（PrP）的内吞作用，并导致质膜释放 PrP。
Other Notes
菲律平 III 是菲律平中 8 种异构体的主要成分。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
涉药品监管产品
此项目有
[Assembly of actin filaments induced by sequestration of membrane cholesterol in transformed cells].
T N Efremova et al.
Tsitologiia, 54(6), 508-514 (2012-09-25)
Cholesterol is one of the major lipid components of plasma membrane and it plays an important role in various signaling processes in mammalian cells. Our study focused on the role of membrane cholesterol in organization and dynamics of actin cytoskeleton.
Dimitri Moreau et al.
EMBO reports, 20(7), e47055-e47055 (2019-07-04)
Most cells acquire cholesterol by endocytosis of circulating low-density lipoproteins (LDLs). After cholesteryl ester de-esterification in endosomes, free cholesterol is redistributed to intracellular membranes via unclear mechanisms. Our previous work suggested that the unconventional phospholipid lysobisphosphatidic acid (LBPA) may play
Henrik Tjellström et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(4), 1128-1138 (2009-12-08)
As in other eukaryotes, plant plasma membranes contain sphingolipids, phospholipids, and free sterols. In addition, plant plasma membranes also contain sterol derivatives and usually <5 mol% of a galactolipid, digalactosyldiacylglycerol (DGDG). We earlier reported that compared to fully fertilized oats
Patrycja Kozik et al.
Nature cell biology, 15(1), 50-60 (2012-12-25)
Clathrin-mediated endocytosis is essential for a wide range of cellular functions. We used a multi-step siRNA-based screening strategy to identify regulators of the first step in clathrin-mediated endocytosis, formation of clathrin-coated vesicles (CCVs) at the plasma membrane. A primary genome-wide
Christophe Stenger et al.
Journal of neurochemistry, 123(4), 467-476 (2012-08-23)
Brain lipid homeostasis is important for maintenance of brain cell function and synaptic communications, and is intimately linked to age-related cognitive decline. Because of the blood-brain barrier's limiting nature, this tissue relies on a complex system for the synthesis and
相关内容
Product Information Sheet
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| F4767-5MG | 04061832947563 |
| F4767-1MG | 04061838446060 |
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