F5006
2-氟-2-脱氧-D-葡萄糖
glycosylation inhibitor, glucose analog
别名:
2-脱氧-2-氟-D–葡萄糖, FDG, 2-脱氧-2-氟-D-葡萄糖
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C6H11FO5
化学文摘社编号:
分子量:
182.15
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
产品名称
2-氟-2-脱氧-D-葡萄糖, glycosylation inhibitor, glucose analog
InChI key
ZCXUVYAZINUVJD-UHFFFAOYSA-N
SMILES string
OCC1OC(O)C(F)C(O)C1O
InChI
1S/C6H11FO5/c7-3-5(10)4(9)2(1-8)12-6(3)11/h2-6,8-11H,1H2
Quality Level
assay
≥98.00% (TLC)
form
powder
mol wt
182.15 g/mol
concentration
≤100% (2-Fluoro-2-deoxy-D-glucose)
color
, white to white with yellow cast
mp
174-176 °C
solubility
water: 49.00-51.00 mg/mL, clear, colorless to faintly yellow
storage temp.
2-8°C
正在寻找类似产品? 访问 产品对比指南
Application
2-氟-2-脱氧-D-葡萄糖被用作快速肿瘤检测的示踪剂。它被用作葡萄糖模拟物，以研究辐射和烧伤小鼠的葡萄糖摄取。肿瘤治疗研究使用FDG联合PET（正电子发射地形图）
Biochem/physiol Actions
抑制细胞糖基化的葡萄糖类似物。
General description
2-氟-2-脱氧-D-葡萄糖无毒，是葡萄糖的结构类似物，显著抑制了糖基化。作为葡萄糖类似物，2-氟-2-脱氧-D-葡萄糖在大脑和心脏细胞中可被迅速摄取。
2-氟-2-脱氧-D-葡萄糖可以被细胞吸收，但不进行代谢性糖酵解。
2-氟-2-脱氧-D-葡萄糖可以被细胞吸收，但不进行代谢性糖酵解。
hcodes
signalword
Warning
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
G J Bosman et al.
Biochimica et biophysica acta, 696(3), 285-289 (1982-03-29)
Tunicamycin, 2-deoxy-D-glucose and 2-deoxy-2-fluoro-D-glucose inhibit dimethyl sulfoxide-induced differentiation of Friend cells. This inhibition, characterized by inhibition of hemoglobin synthesis, is accompanied by a specific inhibition of protein glycosylation. The results of cloning experiments indicate that this inhibition specifically affects cells
Frank J Brooks et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(1), 37-42 (2013-11-23)
The number of studies in the literature involving quantification of the metabolic heterogeneity seen in (18)F-FDG PET images has increased sharply over recent years. We hypothesized that inclusion of very small regions of interest as unique data points will have
C J Hoekstra et al.
European journal of nuclear medicine, 27(6), 731-743 (2000-07-20)
[18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) is considered a valuable tool in the diagnosis and staging of cancer. In addition, it seems promising as a technique to monitor response to therapy. Progress is hampered, however, by the fact that various
Dennis Vriens et al.
Cancer, 117(20), 4582-4594 (2011-03-25)
Indeterminate results at fine-needle aspiration biopsy (FNAB) of thyroid nodules pose a clinical dilemma, because only 20% to 30% of patients suffer from malignancy. Previous studies suggested that the false-negative ratio of [(18)F]-2-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) is very low; therefore
Maarten J Vosselman et al.
The American journal of clinical nutrition, 98(1), 57-64 (2013-05-31)
Studies in rodents have shown that brown adipose tissue (BAT) is activated on food intake, thereby reducing metabolic efficiency. The current study investigated whether a single high-calorie, carbohydrate-rich meal activates BAT in lean human adults. BAT activity was studied in
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持